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Oriented draining dressing with effect of keeping wound moderate wetting and preparation method thereof

A directional and moisturizing technology, applied in dressings, viscous dressings, medical science and other directions, can solve the problems of limited bacteriostatic effect and difficulty in maintaining moderately moist wounds, and achieve excellent antibacterial effect, low cost and good application prospects.

Active Publication Date: 2019-09-24
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the problem that the wound dressing in the prior art is difficult to keep the wound moderately moist and has limited antibacterial effect, and to provide a directional fluid-conducting dressing that maintains the wound moderately moist and its preparation method

Method used

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  • Oriented draining dressing with effect of keeping wound moderate wetting and preparation method thereof

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Effect test

Embodiment 1

[0037] A preparation method for a directional fluid-conducting dressing that maintains a moderately moist wound, the steps of which mainly include:

[0038] (1) With one side surface of the chitosan nonwoven fabric with a thickness of 50 μm as the receiving surface, the pectin solution with a concentration of 5wt% is carried out by electrospinning to form a pectin nanofiber film with a thickness of 50 μm, and the voltage of the electrospinning is 10kV, the receiving distance is 10cm, and the perfusion rate of spinning solution is 0.2mL / h;

[0039] (2) Immerse the composite film formed by chitosan nonwoven fabric and pectin nanofiber film into saturated calcium chloride ethanol solution to carry out crosslinking reaction, the temperature of crosslinking reaction is normal temperature, and the time is 10min;

[0040] (3) The dispersion liquid I of bacterial cellulose is coated on the surface of the pectin nanofiber membrane by dip coating process to form a bacterial cellulose ul...

Embodiment 2

[0054] A preparation method for a directional fluid-conducting dressing that maintains a moderately moist wound, the steps of which mainly include:

[0055] (1) With one side surface of the chitosan nonwoven fabric with a thickness of 60 μm as the receiving surface, the dialdehyde pectin solution with a concentration of 10 wt% is electrospun to form a dialdehyde pectin nanofiber film with a thickness of 60 μm, and the electrospinning The voltage of the silk is 20kV, the receiving distance is 20cm, and the perfusion speed of the spinning solution is 2mL / h;

[0056] (2) the composite film that chitosan nonwoven fabric and dialdehyde pectin nanofiber film forms is immersed in the adipic acid dihydrazide ethanol solution of concentration 1wt% and carries out cross-linking reaction, and the temperature of cross-linking reaction is normal temperature, and the time is 20min;

[0057] (3) The dispersion liquid I of bacterial cellulose is coated on the surface of the dialdehyde pectin...

Embodiment 3

[0062] A preparation method for a directional fluid-conducting dressing that maintains a moderately moist wound, the steps of which mainly include:

[0063] (1) take one side surface of the chitosan nonwoven fabric of thickness 100 μ m as receiving surface, the konjac glucomannan solution that concentration is 15wt% carries out electrospinning and forms the konjac glucomannan nanofiber membrane of thickness 80 μ m, The voltage of electrospinning is 50kV, the receiving distance is 30cm, and the perfusion speed of spinning solution is 5mL / h;

[0064] (2) The composite film that chitosan nonwoven fabric and konjac glucomannan nanofiber film forms is immersed in the adipic acid dihydrazide ethanol solution of concentration 5wt% and carries out cross-linking reaction, and the temperature of cross-linking reaction is normal temperature, time 60min;

[0065] (3) The dispersion liquid I of bacterial cellulose is coated on the surface of the konjac glucomannan nanofiber membrane by di...

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Abstract

The invention relates to an oriented draining dressing with an effect of keeping a wound moderate wetting and a preparation method thereof. The oriented draining dressing with the effect of keeping a wound moderate wetting has a composite layer structure, and comprises a hydrophilic layer, a moisturizing layer and a volatile layer which are adjacent one another, wherein the hydrophilic layer, the moisturizing layer and the volatile layer have porous structures and gradually reduced pore diameters; and the hydrophilic layer is made of a hydrophilic material having a moisture regain of less than or equal to 5 percent, and the moisturizing layer is made of a hydrophilic material having a moisture regain of more than or equal to 100 percent. The preparation method comprises the following steps: respectively forming a polysaccharide B nanofiber membrane and a hydrophobic layer on two side surfaces of a polysaccharide A non-woven fabric; and forming a bacterial cellulose ultrafine reticular fiber membrane on the surface of the polysaccharide B nanofiber membrane to prepare the oriented draining dressing with the effect of keeping a wound moderate wetting. The oriented draining dressing with the effect of keeping a wound moderate wetting can be used for keeping a wound moderate wetting for a relatively long period, and has an excellent antibacterial effect. The preparation method of the oriented draining dressing with the effect of keeping a wound moderate wetting is relatively low in cost, and has an excellent application prospect.

Description

technical field [0001] The invention belongs to the technical field of dressings, and relates to a directional fluid-conducting dressing for keeping wounds moderately moist and a preparation method thereof. Background technique [0002] Wounds on the surface of the skin, including burns, physical injuries, and chemical injuries, will produce a high level of wound exudate during the wound repair process. Excessive fluid accumulation will overhydrate the wound and irritate the surrounding normal skin, causing Skin infections and allergic reactions that prevent wounds from healing themselves. Traditional hydrophilic dressings can absorb part of wound exudate, but due to its uniform wettability, part of the exudate usually remains on the side of the dressing that is in contact with the wound, hindering wound recovery. An ideal wound dressing should keep the wound in a moderately moist environment, which can absorb the exudate on the wound surface in time without forming fluid, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61L15/24A61L15/26A61L15/28A61L15/46
CPCA61F13/0203A61F13/0223A61L15/24A61L15/26A61L15/28A61L15/46C08L5/08
Inventor 王先锋缪东洋丁彬俞建勇
Owner DONGHUA UNIV
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