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Colorectal cancer judgment model for distinguishing cancer tissue of colorectal cancer from paracancerous normal tissue and establishing method of colorectal cancer judgment model

A colorectal cancer and construction method technology, applied in the field of genetic engineering, can solve the problems of low repeatability of molecular markers, low positive rate of molecular markers, failure to meet the standards for early diagnosis of colorectal cancer, etc.

Inactive Publication Date: 2019-09-20
ZHEJIANG UNIV
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Problems solved by technology

First of all, the positive rate of molecular markers discovered so far is not high, and many of them cannot meet the standards for early diagnosis of colorectal cancer; , different detection methods

Method used

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  • Colorectal cancer judgment model for distinguishing cancer tissue of colorectal cancer from paracancerous normal tissue and establishing method of colorectal cancer judgment model
  • Colorectal cancer judgment model for distinguishing cancer tissue of colorectal cancer from paracancerous normal tissue and establishing method of colorectal cancer judgment model
  • Colorectal cancer judgment model for distinguishing cancer tissue of colorectal cancer from paracancerous normal tissue and establishing method of colorectal cancer judgment model

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Embodiment 1

[0048] In 90 pairs of colorectal cancer tissue specimens and paired adjacent normal tissue specimens in the TCGA data, according to the methylation levels of CpG sites listed in Table 3 and the corresponding coefficients, each case is obtained by adding up. The methylation risk index of tissue samples found that the median methylation risk index of tumor tissue samples was 1.06 (1.03, 1.07), and the methylation risk index of normal tissue samples was 0.62 (0.02, 0.11). The difference was statistically significant (P=2.41*10 -54 ); through the analysis of the subject characteristic curve (ROC curve), it was found that the area under the ROC curve of the methylation risk index was as high as 1; when the cutoff value was 0.583, the sensitivity and specificity were both 1.

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Abstract

The invention discloses a colorectal cancer judgment model for distinguishing cancer tissue of colorectal cancer from paracancerous normal tissue and an establishing method of the colorectal cancer judgment model. The method includes: selecting 107 genes related to colorectal cancer with methylation differences in the promoter region of the genes; verifying the expression of the 107 genes and the level of methylation in the promoter region by the aid of patients with both methylation and gene expression data in a TCGA (the cancer genome atlas) database, wherein a total of 37 genes are successfully verified, and 371 CpG sites are located in the promoter regions thereof; screening the 371 CpG sites by the aid of the data in the TCGA database, wherein a total of 78 CpG sites is selected; for the 78 CpG sites and on the basis of the data in the TCGA database, establishing the colorectal cancer judgment model by the aid of the elastic network algorithm. With the method, a theoretical basis is provided for blood screening of colorectal cancer in the future.

Description

technical field [0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a colorectal cancer discrimination model for distinguishing colorectal cancer cancer tissues and adjacent normal tissues and a construction method thereof. Background technique [0002] Colorectal cancer is a common malignant tumor of the digestive tract. According to the International Center for Research on Cancer of the World Health Organization, there were about 1.36 million new cases of colorectal cancer in the world in 2012, ranking third among malignant tumors, after lung cancer and breast cancer. ; About 690,000 deaths, ranking fourth in malignant tumors after lung cancer, liver cancer and gastric cancer. With the change of dietary structure and lifestyle of Chinese residents, the incidence and mortality of colorectal cancer are on the rise. In 2013, the incidence of colorectal cancer ranked third among malignant tumors, and the mortality ranked fou...

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/118C12Q2600/154
Inventor 朱益民来茂德孙晓慧
Owner ZHEJIANG UNIV
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