Fructose nonenzymatic electrochemical sensor and detection method thereof

Abstract

The invention relates to a fructose nonenzymatic electrochemical sensor and a detection method thereof. Platinum-graphene oxide nanoflower is assembled on a working electrode to prepare a fructose sensor based on the processing; under a neutral solution condition, the fructose and the glucose have characteristics of different oxidation potentials under the effect of the platinum-graphene oxide nanoflower, and the fructose oxidation signal can be specifically recognized by using an electrochemical amperometry, thereby reaching an aim of detecting the fructose. The influence on a fructose detection result by an interferent is reduced when a self-reference recording method in a dual-working electrode mode is used for detecting fructose, and a faster method is provided for the detection of thefructose in the medical treatment and food industry.

Description

technical field [0001] The invention relates to a novel non-enzyme electrochemical sensor for fructose and a detection method thereof, which is particularly suitable for simple and fast detection of fructose in a neutral solution and belongs to the technical field of electrochemical sensors. Background technique [0002] Simple and rapid detection of fructose content is very important in clinical diagnosis and industrial food quality control. There are many detection methods for fructose, such as liquid chromatography, near-infrared spectroscopy and electrochemical methods. Due to the characteristics of easy operation, low cost and high time resolution, electrochemical detection methods have attracted much attention in recent years. In the past decade, the electrochemical detection of fructose has mainly relied on enzyme-based biosensors. Although enzyme-based biosensors have high selectivity and sensitivity for detecting substances, in practice, inherent instability or en...

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Problems solved by technology

[0003] The literature so far shows that only a few non-enzymatic sensors can be used for fructose detection, and they have different technical limitations in application. The most obvious technical defect is that it can only be detected in strong acidic or strong alkaline solutions. Fructose, however, most clinical samples are neutral solutions, which means that using the above method to detect the content of fructose in clinical samples requires pretreatment of the samples, thus increasing unnecessary complexity and human interference in the operation , may also increase the uncertainty of the detection results due to the complexity of the reaction process

In addition, there are some non-enzyme sensors that require electrochemical methods such as differential pulse voltammetry for fructose detection. These methods have high sensitivity to analytes, but the analysis and calibration methods are relatively complicated and the detection speed is relatively slow.

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