Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A fluorescent probe for detecting cyanide ions and its preparation method and application

A fluorescent probe, cyanide ion technology, applied in the field of fluorescent probes, can solve the problems of difficult to identify anions, complex probe synthesis, non-repeatable identification, etc., and achieve high selectivity and sensitivity, good application prospects, and response speed. quick effect

Active Publication Date: 2021-07-20
SHANGHAI INST OF TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, people have designed and synthesized many anion fluorescent probes with potential application value, but most of the probes are complicated to synthesize, high in cost, cannot be reproducibly identified, and it is difficult to identify anions in aqueous solution.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A fluorescent probe for detecting cyanide ions and its preparation method and application
  • A fluorescent probe for detecting cyanide ions and its preparation method and application
  • A fluorescent probe for detecting cyanide ions and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] 1. Synthesis of BODIPY 1 molecule, a fluorescent probe for detecting cyanide ions

[0056] The synthesis of the fluorescent probe molecule for detecting cyanide ion in the present invention is obtained by using pyrrole and benzaldehyde as raw materials through condensation, bromination, oxidation, fluoroboration, and nucleophilic substitution reaction with benzyl nitrile.

[0057] (1) Synthesis:

[0058] Benzaldehyde (5.00g, 47.20mmol), pyrrole (20mL, 289mmol) and anhydrous CH 2 Cl 2 (250 mL) was added into a 500 mL round-bottomed flask, which was replaced with a nitrogen system, then trifluoroacetic acid (200 mg, 2.60 mmol) was added to the mixture, and the reaction was stirred at room temperature for 2 h. After the reaction was complete, it was washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate, the filtrate was collected, concentrated, and purified by silica gel column chromatography (petroleum ether: eth...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a fluorescent probe for detecting cyanide ions and its preparation method and application. The fluorescent probe uses boron fluoride dipyrrole (BODIPY) as a fluorescent signal group and an activated CH group in a phenylacetonitrile group. A cyanide ion fluorescent probe for the recognition site, which is obtained by nucleophilic substitution reaction of 3,5-dibromo-8-phenylboron fluoride dipyrrole and benzyl nitrile. Through the study of ultraviolet absorption and fluorescence emission spectroscopy, it is found that the probe can uniquely recognize cyanide ion, and the lowest detection limit in 70% aqueous solution can reach 148nM, and the recognition process is not interfered by other anions. Compared with the prior art, the synthetic method of the fluorescent probe of the present invention is simple, the raw material is easy to obtain, the cost is low, the selectivity to cyanide ion is good, the sensitivity is high, has reversibility and can be detected in aqueous solution, so in the It has a good application prospect in the detection of cyanide ion.

Description

technical field [0001] The invention relates to the field of fluorescent probes, in particular to a fluorescent probe for detecting cyanide ions, a preparation method and application thereof. Background technique [0002] Anions widely exist in nature and organisms, and play an important role in environmental science, clinical medicine, chemistry, biology and other fields. Among the many anions, cyanide ion has extremely high toxicity to the human body. The poisoning mechanism is that the cyanide ion can complex with the ferric ion of cytochrome oxidase, resulting in the loss of the ability of the ferric iron to transfer electrons, making the respiratory chain Interruption, eventually leading to human death due to lack of oxygen. In addition, cyanide ion also plays a very important role in synthetic fibers, leather products, metallurgical industry and electroplating technology, but the extensive use of cyanide in industrial production will inevitably cause harm to organisms...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/02C09K11/06G01N21/64
CPCC07F5/022C09K11/06C09K2211/1007C09K2211/1029C09K2211/1055G01N21/643G01N2021/6432
Inventor 刘传祥付超李喆垚饶才辉陈璐朱婷婷
Owner SHANGHAI INST OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com