A kind of preparation method and application of mesoporous organosilica-coated ferric oxide embolism microspheres

An organic silicon oxide and ferric oxide technology, which can be used in the preparation of microspheres, microcapsule preparations, and preparations for in vivo tests, etc. The effect of large clinical translation value, uniform size, and good embolization effect

Active Publication Date: 2022-02-01
滕兆刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of the above-mentioned problems, in order to overcome the shortcomings in the clinical application of the existing embolic microspheres, such as uneven size and difficulty in monitoring embolic microspheres, the present invention provides a mesoporous organosilica-coated ferric oxide embolic microsphere, which will It is used for interventional embolization therapy, not only has a uniform size, but also can be used for magnetic resonance imaging, so as to achieve effective embolization of tumors and monitor the effect of embolization

Method used

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  • A kind of preparation method and application of mesoporous organosilica-coated ferric oxide embolism microspheres
  • A kind of preparation method and application of mesoporous organosilica-coated ferric oxide embolism microspheres
  • A kind of preparation method and application of mesoporous organosilica-coated ferric oxide embolism microspheres

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Effect test

Embodiment 1

[0030] (1) Preparation of magnetic Fe by hot solvent method 3 o 4 Nanoparticles. The specific method is: 0.65g FeCl 3 , 0.2g sodium citrate, and 1.2g sodium acetate were dissolved in 20mL ethylene glycol and stirred evenly by magnetic force, then transferred to a 30mL reactor and reacted at 200°C for 10h, after cooling to room temperature, washed three times with deionized water, vacuum Oven drying for 12 hours to obtain magnetic ferric oxide particles;

[0031] (2) 0.2g of the above-prepared Fe 3 o 4 Nanoparticles were dispersed in 800mL water-alcohol solution (alcohol-water ratio 3:1), ultrasonically dispersed, then 10mL 25wt% ammonia water and 100mL TEOS were added, stirred at room temperature for 6h, centrifuged and washed with ethanol three times;

[0032] (3) Disperse the product of the above (2) into 1000mL alcohol water solution, alcohol water 8:1, add 1g CTAB surfactant, stir at room temperature for 1h, add 5mL 25wt% ammonia water, 100mL TEOS+BTSE mixed silicon s...

Embodiment 2

[0037] (1) Preparation of magnetic Fe by hot solvent method 3 o 4 Nanoparticles: 0.65g FeCl 3 , 0.2g sodium citrate, and 1.2g sodium acetate were dissolved in 20mL ethylene glycol and stirred evenly by magnetic force, then transferred to a 30mL reactor and reacted at 200°C for 10h, after cooling to room temperature, washed three times with deionized water, 60°C Dry in a vacuum oven for 12 hours to obtain magnetic ferric oxide particles;

[0038](2) 0.2g of the above-prepared Fe 3 o 4 Nanoparticles were dispersed in 800mL hydroalcoholic solution, the volume ratio of ethanol and water was 3:1, ultrasonically dispersed, then 10mL 25wt% ammonia water and 100mL TEOS were added, stirred at room temperature for 6h, centrifuged, and washed with ethanol three times;

[0039] (3) Disperse the product of step 2 into 1000mL alcohol aqueous solution, the volume ratio of ethanol and water is 8:1, add 3gCTAB surfactant, stir at room temperature for 1h, add 15mL 25wt% ammonia water, 300mL...

Embodiment 3

[0043] (1) Preparation of magnetic Fe by hot solvent method 3 o 4 Nanoparticles: 0.65g FeCl 3 , 0.2g sodium citrate, and 1.2g sodium acetate were dissolved in 20mL ethylene glycol and stirred evenly by magnetic force, then transferred to a 30mL reactor and reacted at 200°C for 10h, after cooling to room temperature, washed three times with deionized water, 60°C Dry in a vacuum oven for 12 hours to obtain magnetic ferric oxide particles;

[0044] (2) 0.2g of the above-prepared Fe 3 o 4 Nanoparticles were dispersed in 800mL hydroalcoholic solution, the volume ratio of ethanol and water was 3:1, ultrasonically dispersed, then 10mL 25wt% ammonia water and 100mL TEOS were added, stirred at room temperature for 6h, centrifuged, and washed with ethanol three times;

[0045] (3) Disperse the product of step 2 into 1000mL alcohol aqueous solution, the volume ratio of ethanol and water is 4:1, add 3gCTAB surfactant, stir at room temperature for 1h, add 15mL 25wt% ammonia water, 300m...

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Abstract

The invention discloses a preparation method and application of mesoporous organosilica-wrapped ferric oxide embolic microspheres, mainly to solve the existing problems of non-uniform embolic microspheres and difficult real-time monitoring. Ferric oxide nanoparticles as the core, surfactants as templates, inorganic and organic mixed silanes as silicon source precursors, and mesoporous organic oxides grown on the surface of ferric oxide through a sol-gel process in an alcoholic aqueous solution Silicon shell layer, the magnetic mesoporous silicon oxide microspheres obtained by this method can reach a particle size of 50‑400 μm, with uniform size and good dispersion. The magnetic mesoporous silicon oxide microspheres can be used for interventional embolization therapy of tumors, have the performance of magnetic resonance imaging, and can monitor the embolization therapy process dynamically in real time.

Description

technical field [0001] The invention belongs to the field of advanced materials, and in particular relates to a mesoporous organic silicon oxide-wrapped ferric iron tetroxide plug microsphere, a preparation method and application thereof. Background technique [0002] Cancer is a highly lethal disease that poses a great threat to human life and health. Interventional embolization therapy is a commonly used method for clinical treatment of cancer, and the performance of embolizing agents will determine the effect of treatment. At present, lipiodol is commonly used clinically as an embolic agent. This liquid embolic agent is effective for the embolization of tiny tumor blood vessels, but it is difficult to tie down the arteries supplying blood to the tumor, which is likely to cause tumor recurrence. In addition, the liquid embolic agent is unstable and prone to Cause embolism ectopic, affect the function of normal body. [0003] Embolization microspheres are a new type of emb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02A61K49/08A61K49/18A61L31/02A61L31/14
CPCB01J13/02A61K49/183A61K49/08A61L31/028A61L31/14A61L2300/416
Inventor 滕兆刚苏晓丹党萌
Owner 滕兆刚
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