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Formula for prevention and treatment of acute severe pancreatitis combined with liver damage

A technology for pancreatitis and liver damage, applied in the field of traditional Chinese medicine formulas for the treatment of acute severe pancreatitis, can solve the problems of poor acceptance of severe patients, inability to treat patients based on syndrome differentiation, high cost of western medicine, etc. convenient effect

Inactive Publication Date: 2019-08-30
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently clinically applied traditional Chinese medicines include Qingyi Decoction, Chai Qin Cheng Qi Decoction, Bupleurum Cheng Qi Decoction and other prescriptions. However, the high cost and side effects of western medicines cannot be ignored at present.
However, traditional Chinese medicine prescriptions have disadvantages such as troublesome production, large quantity, bitter taste, and poor acceptance by critically ill patients.
At the same time, since it is impossible to treat each patient according to syndrome differentiation, what cannot be avoided is the disadvantage of "a party of one thousand people"

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, a kind of formula for the prevention and treatment of acute severe pancreatitis combined with liver damage, including the prevention phase formula and the treatment phase formula, the specific formula is as follows:

[0021] Prevention stage: Scutellaria baicalensis 0.01-0.05 grams + Salvia miltiorrhiza 0.01-0.015 grams / Kg body weight;

[0022] Treatment stage: Scutellaria baicalensis 0.01-0.05 grams + Salvia miltiorrhiza 0.02-0.03 grams / Kg body weight.

[0023] The specific experimental method is as follows:

[0024] 1. Materials and methods

[0025] 1.1 Grouping of animals: 70 Wistar rats, male or female, weighing (320±50) g.

[0026] They were randomly divided into 12 groups, see Table 1.

[0027] group 4h 8h 24h control group 4 4 4 pancreatitis ASP group 4 4 4 Scutellaria baicalensis + Salvia miltiorrhiza low dose group 4 4 4 Scutellaria baicalensis + Salvia miltiorrhiza high dose group 4 4 4

[0028]...

Embodiment 2

[0050] Embodiment 2, a preparation method of a prescription for the prevention and treatment of acute severe pancreatitis combined with liver damage, the specific method is as follows: 1, extraction: put 40-60 parts of Scutellaria baicalensis pieces and 40-60 parts of Salvia miltiorrhiza into 20- In a container of water at 30°C, add 8 times the total weight of Scutellaria baicalensis and Danshen decoction pieces, soak for 30-60 minutes, decoct and extract the soaked medicinal materials, heat to boiling with fire, and then heat slowly for 2 hours after boiling , the decoction extraction process parameters include: the extraction pressure is 0.06-0.12MPa, and / or the extraction temperature is 100-110°C, and / or the extraction time is 30-60min, the above operation is repeated at least 3 times, and then the above obtained The extracts are mixed;

[0051] 2. Separation: The extract is subjected to solid-liquid separation. The solid-liquid separation adopts high-speed separation and p...

Embodiment 3

[0055] Embodiment 3. A method of using a therapeutic formula for acute severe pancreatitis complicated with liver damage. Take the granules twice a day in the morning and evening with water, and avoid eating stimulating food.

[0056] Analysis of prescriptions and prescriptions: Scutellaria baicalensis: "New Compendium of Materia Medica" says: Scutellaria baicalensis, bitter in taste, calm in gas, cold in nature, can rise or fall, slightly yang in yin, non-toxic. Go into lung meridian, large intestine. Reducing fever and relieving restlessness, purging bladder fire, stopping red dysentery, eliminating red eyes, relieving typhoid fever stagnation and steaming, moistening dryness.

[0057] Danshen: "Materia Medica New Edition" said: slightly cold. Bitter. Non-toxic. The main confidant is evil. Bowel sounds faint like running water. Accumulation of cold and heat. Break the disease and eliminate the lump. Stop bothering and replenish Qi. Danshen is slightly cold. Endowed ...

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PUM

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Abstract

The present invention discloses a formula for prevention and treatment of acute severe pancreatitis combined with liver damage. The formula comprises a formula in a prevention stage and a formula in atreatment stage. The specific formula is as follows: in the prevention stage: 0.01-0.05 g / Kg body weight of radix scutellariae + 0.01-0.015g / Kg body weight of radix salviae miltiorrhizae; and in thetreatment stage: 0.01-0.05 g / Kg body weight of radix scutellariae + 0.02-0.03 g / Kg body weight of radix salviae miltiorrhizae. The formula has the prevention function on high-risk populations, has a certain degree of remission and control effects on occurrence and development of the disease, and effectively alleviates severity of the acute severe pancreatitis combined with the liver damage, breaksa limitation of "one prescription for thousand people" of traditional medicines using body weight as a basis for medicine use, enables the medicine use to be personalized and quantified as much as possible, conducts precautionary intervention on the high-risk populations in an early stage, groups, conducts early small dose prevention, can comprehensively adjust human body functions, is slightly increased in the medicine use dosage after the onset, can enable severity to be reduced and treatment difficulty to be low after the onset of patients, can be smoothly absorbed by human body, enables digestive system functions to be slowly and orderly restored, can promote rehabilitation and facilitates long-term stability in the future.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine formulas for treating acute severe pancreatitis, in particular to a formula for preventing and treating acute severe pancreatitis complicated with liver damage. Background technique [0002] With the development of the economy and the improvement of people's living standards, the proportion of high-fat, high-protein, and high-sugar diets is relatively high. The factors that induce acute severe pancreatitis, such as cholelithiasis, overeating, and alcohol consumption, are increasing year by year. Acute severe pancreatitis is nearly 40 The number of critical, acute, and severe cases increasing year by year in clinical practice may be combined with damage to multiple organs such as liver, kidney, and lung, and multi-system failure may occur. The mortality rate can reach 8-10%, and the economic burden and mental burden are heavy. [0003] Most patients with severe acute pancreatit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61P1/18
CPCA61K36/537A61K36/539A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P1/18A61K2300/00
Inventor 黄朔
Owner JIAMUSI UNIVERSITY
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