Method for determining dopamine, uric acid and ascorbic acid at same time by virtue of carbon nanocomposite modified electrode

Abstract

The invention establishes a method for determining dopamine, uric acid and ascorbic acid at the same time by virtue of a nitrogen doped porous carbon-nitrogen doped graphene nanocomposite modified electrode. A solvothermal method is adopted for preparing a Zn-based zeolite imidazate framework material (ZIF-8), the ZIF-8 is taken as a precursor, high temperature carbonization is performed for preparing nitrogen doped porous carbon (NPC), and then a nitrogen doped graphene (NGR)-NPC composite is prepared. A glassy carbon electrode (GCE) is taken as a basal electrode and Nafion is taken as a fixed film for preparing Nafion-NGR-NPC/GCE. The modified electrode shows good electro-catalytic capability on the dopamine, uric acid and ascorbic acid, and a satisfactory result is obtained when the method provided by the invention is applied to content determination on dopamine, uric acid and ascorbic acid in a biological sample.

Description

Technical field [0001] The invention relates to a nitrogen-doped graphene-nitrogen-doped porous carbon composite nano material used in the preparation of chemically modified electrodes and the detection method field of dopamine, uric acid and ascorbic acid content in biological samples. Background technique [0002] Zeolite-like imidazole framework materials (ZIFs) are formed by the connection of metal ions and imidazole ligands. They have a three-dimensional tetrahedral structure similar to the zeolite topological structure, exhibit good thermal and chemical stability, and are widely used for absorption, Catalysis and electrochemical sensing and other fields. ZIF-8 is formed by the coordination of zinc nitrate and 2-methylimidazole, and forms a sodalite topology through further aggregation. With ZIF-8 as the precursor, nitrogen-doped porous carbon (NPC) is formed after calcination. It has the following excellent characteristics: First, the lone pair of electrons of the nitrogen...

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Problems solved by technology

However, when traditional electrodes measure dopamine, uric acid and ascorbic acid, the oxidation

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