Composition and preparation method and application thereof
A composition and technology of pyridoxine hydrochloride, applied in the field of dermatology, can solve problems such as side effects, high price, scalp irritation and the like
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[0051] The preparation method of composition provided by the invention comprises steps:
[0052] In the first step, zinc sulfate and pyridoxine hydrochloride are mixed in a citric acid-sodium citrate buffer solution to obtain solution 1;
[0053] In the second step, sodium hyaluronate is mixed with solution 1 to obtain solution 2;
[0054] In the third step, the solution 2 is mixed with the solution 3 to obtain the composition provided by the present invention; the solution 3 is obtained by mixing the polypeptide complex and water.
[0055] In one embodiment of the present invention, the above-mentioned first step is to dissolve the zinc sulfate and pyridoxine hydrochloride of formula quantity in citric acid-sodium citrate buffer solution; The composition of citric acid-sodium citrate buffer solution is lemon acid, sodium citrate, sodium chloride and water for injection.
[0056]In a preferred embodiment of the present invention, the pH of the buffer solution used in the abo...
Embodiment 1
[0080] Gel to prevent hair loss, promote hair growth and protect hair strands
[0081] Its formula is characterized by quality concentration The meter contains the following components: 500ppm copper peptide, 500ppm biotin tripeptide-1, 500ppm acetyl tetrapeptide-3, 500ppm decapeptide-18, 5.0wt% pyridoxine hydrochloride, 5.0wt% zinc sulfate and 5.0wt% hyaluronic acid Sodium acid.
[0082] Its preparation method is as follows:
[0083] Step 1: 5.0wt% pyridoxine hydrochloride and 5.0wt% zinc sulfate were dissolved in citric acid-sodium citrate buffer solution, and sterilized by filtration with a 0.22 μm aqueous filter membrane.
[0084] Step 2: Add 5.0wt% sodium hyaluronate into the sterilized solution in Step 1, stir mechanically for 36 hours, and fully dissolve.
[0085] Step 3: Dissolve 500ppm copper peptide, 500ppm biotin tripeptide-1, 500ppm acetyl tetrapeptide-3, and 500ppm decapeptide-18 in water for injection under the laminar flow hood, filter and sterilize with a 0...
Embodiment 2
[0088] Gel to prevent hair loss, promote hair growth and protect hair strands
[0089] Its formula contains the following components in mass concentration:
[0090] 1ppm copper peptide, 1ppm biotin tripeptide-1, 1ppm acetyl tetrapeptide-3, 1ppm decapeptide-18, 0.01wt% pyridoxine hydrochloride, 0.01wt% zinc sulfate and 0.01wt% sodium hyaluronate.
[0091] Its preparation method is as follows:
[0092] Step 1: 0.01wt% of pyridoxine hydrochloride and 0.01wt% of zinc sulfate are dissolved in citric acid-sodium citrate buffer solution, and sterilized by moist heat.
[0093] Step 2: Add 0.01wt% sodium hyaluronate to the sterilized solution in Step 1, and shake it on a shaker for 12 hours to fully dissolve.
[0094] Step 3: Dissolve 1ppm copper peptide, 1ppm biotin tripeptide-1, 1ppm acetyl tetrapeptide-3, and 1ppm decapeptide-18 in water for injection under the laminar flow hood, filter and sterilize with a 0.22μm water-based filter membrane, 25 Slowly add the polypeptide solutio...
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