Multi-channel artificial nerve catheter and preparation method thereof

Abstract

The invention relates to a multi-channel artificial nerve catheter and a preparation method thereof. The multi-channel artificial nerve catheter can be used for customized bridging repair of far and near ends of a nerve defect site. The multi-channel artificial nerve catheter capable of performing customized imitation on a natural anatomical structure of nerves mainly comprises a multi-channel stent (neural catheter tube body) imitating the natural anatomical structure of the nerves and a biofilm structure (neural catheter tube wall) wrapping the outer layer of the multi-channel stent. The tube multi-channel structure can form a better customized matching relation with nerve tract tissue of different sizes in different areas of the to-be-repaired nerves, and by guiding specific nerve tracttissue at the near ends of the nerve defect site in reaching the far ends in different customized channel structures, the decrease of the diverged growth and mutual interweave phenomenon of the nervetracts during growth is achieved, and the decrease of the mismatch rate of near-end new nerve tract tissue with a far-end target region is facilitated.

Description

technical field [0001] The invention relates to the field of nerve conduits, and relates to the design and preparation method of a customized bionic multi-channel artificial nerve conduit that imitates the natural anatomical structure of nerves. Background technique [0002] Peripheral nerve injury is a common clinical problem that often results from severe injury, resulting in neurological deficits. For defects larger than 4 mm, a simple direct suture approach cannot be adopted, but a graft bridge needs to be provided between the proximal and distal ends of the defect. Autologous nerve transplantation is currently the "gold standard" for repairing nerve defects, but it often results in damage to the donor site and incomplete functional recovery. [0003] Nerve conduits have been developed as an alternative to autografts to repair nerve defects, and their structures are currently limited to simple single-channel or multi-channel structures with regular matrices. However, t...

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Problems solved by technology

[0004] Therefore, the current nerve conduit structure is limited to single-channel or regular-matrix multi-channel nerve conduits, which cannot well simulate the arrangement and distribution of nerve bundles in the nerve, and cannot truly restore the three-dimensional space of multiple groups of nerve bundles in the original nerve trunk. None of the above-mentioned nerve conduit structures is the best choice for the restoration of peripheral nerve defects.

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