Sodium hyaluronate hydrogel with fast curing function and preparing method thereof

Abstract

The invention discloses a sodium hyaluronate hydrogel with a fast curing function and a preparing method thereof, and particularly relates to the technical field of biomedical engineering. The sodiumhyaluronate hydrogel is prepared from, by mass, 5%-10% of sodium hyaluronate, 2.5%-5% of methacrylic anhydride, 0.1%-1% of a photoinitiator, 2%-5% of alkaline buffering liquid and the balance deionized water. According to the sodium hyaluronate hydrogel with the fast curing function and the preparing method thereof, the sodium hyaluronate hydrogel has the advantages of fast curing, the excellent biocompatibility and the ideal mechanical strength; the preparing method has the advantages of being high in reaction efficiency, short in reaction time and high in product acylation rate, gelatinizingrate and mechanical strength.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a sodium hyaluronate hydrogel with rapid curing function and a preparation method thereof. Background technique [0002] In the late 1980s, scientists proposed the idea of ​​combining biocompatible scaffold materials with the patient's own cells to construct transplantable functional organs, thereby solving the severe organ shortage problem. This type of scaffold material is usually highly biocompatible and degradable. Through tissue engineering technology, it is mixed with cells in vitro to form a three-dimensional structure. After in vitro culture to make cells proliferate and differentiate, they are implanted in the body to repair or permanently Replace damaged tissues and organs. Because of the above properties, hydrogel has become a research hotspot in the fields of tissue engineering and biomedicine. [0003] Hydrogel is a water-absorbable polymer material ...

AI Technical Summary

Problems solved by technology

However, during the esterification reaction, acidic substances will be produced to affect the pH of the reaction system

Therefore, not only the reaction efficiency is lower, but also the reaction time is greatly prolonged.

At the same time, due to the unoptimized reaction conditions, more methacrylic anhydride will be used in the above preparation method, so that the acylation rate of the product is low, which in turn makes the gelation rate slow and the mechanical strength is low, which is not conducive to 3D printing.

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