Antimicrobial peptide and application thereof

Abstract

The invention discloses an antimicrobial peptide. An amino acid sequence thereof is shown as any one of SEQ ID NO:1-SEQ ID NO:7. The antimicrobial peptide disclosed by the invention is capable of moreefficiently restraining activity of streptococcus mutans under floating state and biofilm state; the antimicrobial peptide has a rapid sterilizing effect, low cytotoxicity and high antibiofilm activity; the antimicrobial peptide has the advantages of simple synthesis and low production cost; the antimicrobial peptide is suitable for mass synthesis and is beneficial to clinical conversion.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an antibacterial peptide and its application. Background technique [0002] Caries is one of the most common oral diseases in which the tooth hard tissue is chronically and progressively destroyed under the influence of bacteria-based factors. It not only affects the beauty and function of teeth, but also causes serious complications such as pulpitis and periapical periodontitis, and can even develop into hidden dangers of systemic diseases such as digestive system diseases and cardiovascular diseases. Dental plaque biofilm is the initiating factor of caries. It is a micro-ecological environment mainly colonized by bacteria on the surface of teeth. It contains a wide variety of bacteria, including both cariogenic bacteria and a large number of non-cariogenic bacteria. , and there are symbiosis, competition and antagonism between bacteria. As the main cariogenic bacteria, Streptococcu...

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Problems solved by technology

[0007] However, the above-mentioned natural antimicrobial peptides and their derivatives, as well as the prior art of targeted antimicrobial peptides, generally have the following two disadvantages: (1) whether it is natural antimicrobial peptides and derivatives thereof, or targeted antimicrobial peptides, they All have relatively long peptide chains, which not only cause the problems of large synthesis consumption and difficult clinical transformation, but also have their own antibacterial effects that may not be fully reflected due to factors such as steric hindrance; (2) current antimicrobial peptides and The antibacterial regions of the targeting peptides all use sequences that are not specifically associated with Streptococcus mutans, so they only have a pure antibacterial effect, and do not necessarily have other anti-caries advantages, such as anti-streptococcus mutans biofilm formation activity

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