C9orf139 and MIR600HG as prognostic markers of pancreatic cancer and establishment method of markers

A prognostic marker, pancreatic cancer technology, applied in the field of gene technology and medicine, can solve problems such as the complex function of ceRNA network

Pending Publication Date: 2019-07-05
辽宁省肿瘤医院
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Problems solved by technology

However, the functions of ceRNA networks are complex and require further exploration

Method used

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  • C9orf139 and MIR600HG as prognostic markers of pancreatic cancer and establishment method of markers
  • C9orf139 and MIR600HG as prognostic markers of pancreatic cancer and establishment method of markers
  • C9orf139 and MIR600HG as prognostic markers of pancreatic cancer and establishment method of markers

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Embodiment Construction

[0036] The method for establishing C9orf139 and MIR600HG as prognostic markers of pancreatic cancer specifically includes the following steps.

[0037] 1. Differential expression analysis.

[0038] Differentially expressed genes in pancreatic cancer tissues were extracted and R3.4.3 was used after logFC absolute value >2 and FDR (adjusted P value) figure 1 .

[0039] 2. Hierarchical cluster analysis.

[0040] In order to explore how differentially expressed lncRNAs, miRNAs and mRNAs in pancreatic cancer are regulated, the present invention completed an unsupervised hierarchical clustering analysis and found that the expression patterns of these genes were significantly differentiated between pancreatic cancer samples and normal samples, Such as figure 2 shown.

[0041] 3. Prediction of targeted lncRNAs by miRNAs using miRcode and starBase.

[0042] After extracting differential lncRNAs and miRNAs, the relationship between miRNAs and lncRNAs was predicted based on miRcode ...

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Abstract

The invention belongs to the field of gene technology and medicine, in particular to C9orf139 and MIR600HG as prognostic markers of pancreatic cancer and an establishment method of the markers. The pancreatic cancer prognosis markers comprise C9orf139 and MIR600HG. By exploring the differentially-expressed mRNA, lncRNA and miRNA in pancreatic cancer, a ceRNA network is constructed to find new molecular screening biomarkers for pancreatic cancer and provide new analytical and molecular mechanisms for lncRNAs, miRNAs and pancreatic cancer mRNA. The invention determines two new biomarkers as potential pancreatic cancer prognosis indicators, and thus the prognosis of pancreatic cancer diseases is improved, and the accuracy of early diagnosis of pancreatic cancer is improved.

Description

technical field [0001] The invention relates to the fields of gene technology and medicine, in particular to C9orf139 and MIR600HG as pancreatic cancer prognostic markers and a method for establishing them. Background technique [0002] Cancer deaths have fallen by 23 percent since 1991, but pancreatic cancer deaths are still rising. Pancreatic cancer has become the fourth leading cause of death among cancer patients in the United States. Patients with pancreatic cancer are usually diagnosed at an advanced stage, where the annual mortality rate nearly equals the incidence rate. However, traditional identifiable clinical and pathological symptoms are flawed in the early diagnosis of pancreatic cancer. To prolong the overall survival of patients with pancreatic cancer, new approaches to the pathogenesis are needed. Accumulating evidence suggests that molecular biomarkers can serve as promising clinical tools for identifying patients with early-stage disease. Therefore, the...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/113
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 王哲李轩
Owner 辽宁省肿瘤医院
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