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Tetrahydrocarbazole structure type androgen receptor antagonist and application thereof

A technology of androgen receptor and antagonist, which is applied in the field of biochemistry, and can solve the problems of developing new AR antagonist drugs, etc.

Active Publication Date: 2019-05-03
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-HBP antagonists targeting other regions of the AR protein can overcome the defects of traditional antagonist drug resistance, and there is still a large clinical gap in this research; the drug development of new AR antagonists has a long way to go

Method used

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  • Tetrahydrocarbazole structure type androgen receptor antagonist and application thereof
  • Tetrahydrocarbazole structure type androgen receptor antagonist and application thereof
  • Tetrahydrocarbazole structure type androgen receptor antagonist and application thereof

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Embodiment 1

[0037] (1) Virtual screening based on molecular docking

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Abstract

The invention discloses a tetrahydrocarbazole structure type androgen receptor antagonist and an application thereof and belongs to the technical field of biochemistry. Two compounds have obvious antagonistic activity on an androgen receptor, so that the compounds can be applied to preparation of the androgen receptor antagonist, a prostate cancer cell proliferation inhibitor and a prostate tumorresisting drug. The invention also provide a pharmaceutical composition containing the compounds as effective components, and a new choice is provided for drug research for treating prostatic cancer at present.

Description

[0001] This application is a divisional application with application number 201710117698.9, application date March 1, 2017, and invention name "androgen receptor antagonist and its application". technical field [0002] The invention relates to the technical field of biochemistry, in particular to androgen receptor antagonists and applications thereof. Background technique [0003] Prostate cancer is the second most deadly tumor in men in western countries. In recent years, with the improvement of people's living standards and changes in diet structure, the incidence of prostate cancer in China has shown a trend of increasing significantly. For patients with limited stage (early stage) prostate cancer, radical prostatectomy and radiotherapy can achieve better results. However, due to the lack of obvious clinical symptoms and hidden disease in the early stage of prostate cancer, and the lack of popularization of screening, many patients are already in the advanced stage of tu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/403A61P35/00
CPCA61K31/341A61K31/352A61K31/366A61K31/403A61K31/4035A61K31/428A61K31/437A61K31/4375A61K31/4704A61K31/4706A61K31/496A61K31/635
Inventor 李丹周文方侯廷军
Owner ZHEJIANG UNIV
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