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Hydrophobic polysaccharide and collagen modulated mineralized hydroxyapatite composite material

A technology of hydroxyapatite and composite materials, which is applied in the field of composite materials of hydroxyapatite, can solve the problems that patients cannot restore the original structure of bones.

Inactive Publication Date: 2019-04-30
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no matter what the situation is, it is impossible to restore the patient's bone structure to its original structure.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Take 1.0 g of commercially available hydrophobic polysaccharide, slowly pour it into 100 ml of collagen solution with a concentration of 5.0%, and pour it while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type III collagen dissolved in 0.2mol / L phosphoric acid. After stirring evenly, stir for 1 hour at an ambient temperature of 23°C. Weigh 20.0 g of calcium chloride, pour it into the above components and stir for 2 hours, and adjust the pH value to 7 with 1.0 mol / L sodium hydroxide solution. The obtained composite material is placed in a rectangular tank of less than 60 meshes for cross-linking and dehydration molding. The mass ratio of polysaccharide to collagen is 1:5; the mass ratio of collagen:calcium chloride is 1:4.

Embodiment 2

[0013] Take 3.0 g of commercially available hydrophobic polysaccharides, slowly pour into 100 ml of collagen solution with a concentration of 5.0%, and pour while stirring. Wherein the collagen solution is a mixed collagen of type I collagen and type III collagen dissolved in 0.5mol / L phosphoric acid. After stirring evenly, stir for 1 hour at an ambient temperature of 10°C. Weigh 20.0 g of calcium chloride, pour it into the above components and stir for 2 hours, and adjust the pH value to 7 with 1.0 mol / L sodium hydroxide solution. The obtained composite material is placed in a rectangular tank of less than 60 meshes for cross-linking and dehydration molding. The mass ratio of polysaccharide to collagen is 3:5; the mass ratio of collagen:calcium chloride is 1:4.

Embodiment 3

[0015] Take 8.0 g of commercially available hydrophobic polysaccharides, slowly pour into 100 ml of collagen solution with a concentration of 5.0%, and pour while stirring. The collagen solution is a mixture of type I collagen and type II collagen dissolved in 0.2mol / L phosphoric acid. After stirring evenly, stir for 20 hours at an ambient temperature of 23°C. Weigh 10.0 g of calcium chloride, pour it into the above components and stir for 2 hours, and adjust the pH value to 7 with 1.0 mol / L sodium hydroxide solution. The obtained composite material is placed in a rectangular tank of less than 60 meshes for cross-linking and dehydration molding. The mass ratio of polysaccharide to collagen is 8:5; the mass ratio of collagen:calcium chloride is 1:2.

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Abstract

The invention provides a plastic repair composite material for damaged parts of skulls, facies frontalis bones, nasal bones and finger bones, belongs to the field of medical biomaterials, and mainly solves the problem that the bones cannot be restored to an original framework after the skulls, the facies frontalis bones, the nasal bones and the finger bones are damaged in clinical treatment at present. Through establishing a balance point between biological reconstruction rate and material degradation absorption rate, postoperative collapse is prevented from occurring and a growth matrix and acreeping channel of osteoblasts are provided to a receptor to achieve the goal of skeleton reconstruction. The material prepared by the method is prepared by the method of carrying out structural reconstruction of hydrophobic polysaccharides and collagen, carrying out collagen re-modulation mineralization of calcium and phosphorus ions to form hydroxyapatite composite materials and finally carrying out cross-linking dehydration molding; the material is a stable, hard and porous material with good biocompatibility. The composite material disclosed by the invention is in favor of the skeleton reconstruction of the damaged parts of the skulls, the facies frontalis bones, the nasal bones and the finger bones.

Description

technical field [0001] The invention relates to a composite material of hydroxyapatite modulated and mineralized by hydrophobic polysaccharide and collagen. This material is hard, porous inside, and has a certain load-bearing capacity. It is used for plastic repair of damaged parts of skull, frontal bone, nasal bone and phalanx. It belongs to the field of medical biomaterials. Background technique [0002] At present, the injury rate of skull, frontal bone, nasal bone and phalanx caused by accidents such as car accidents and high-altitude falls in the world is getting higher and higher. Such skeletal defects also occur due to genetic causes. At present, large wounds are mostly treated with titanium mesh or silica gel, while small wounds are left untreated. However, no matter what the situation is, it is impossible to restore the patient's bone to its original structure. To a large extent, it affects the normal life of the patient and increases the psychological pressure...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/24A61L27/20A61L27/02A61L27/50A61L27/58
CPCA61L27/56A61L27/025A61L27/20A61L27/24A61L27/50A61L27/58A61L2430/02
Inventor 关茜茹
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