Marker for forecasting immunotherapy curative effect of head and neck tumors and application

A head and neck cancer immunotherapy technology, applied in the field of markers to predict the efficacy of head and neck tumor immunotherapy, can solve the problems of lack of efficacy of head and neck tumor immunotherapy

Active Publication Date: 2019-04-05
SUN YAT SEN UNIV CANCER CENT
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Problems solved by technology

However, there is still a lack of markers that can effectively predict the efficacy of head and neck tumor immunotherapy

Method used

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  • Marker for forecasting immunotherapy curative effect of head and neck tumors and application
  • Marker for forecasting immunotherapy curative effect of head and neck tumors and application
  • Marker for forecasting immunotherapy curative effect of head and neck tumors and application

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with specific experiments. It should be understood that the following content is only used to illustrate the present invention and is not intended to limit the protection scope of the present invention.

[0024] Through the cluster analysis of the gene mRNA expression of 522 samples of head and neck tumor patients who underwent RNA sequencing in the training group, it was found that Patients with head and neck cancer were divided into two subgroups with different characteristics, immune type and non-immune type ( figure 1 ), in which the immune-type subgroup of patients highly expressed indicators related to immune activation, such as immune enrichment score (immune enrichment score), immune cell subsets (immune cell subsets), immune signaling molecules (immune signaling molecules), etc., representing immune The subgroup of patients with the immune type may have a greater possibility of benefiting from...

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Abstract

The invention discloses a marker for forecasting an immunotherapy curative effect of head and neck tumors and application. The marker composed of 113 genes can effectively divide patients into an immune type and a nonimmune type, the marker composed of 48 genes is further combined, a patient area can be divided into three subgroups of an immune activation type, an immunodepletion type and the nonimmune type. The immune type is verified through experiments, and especially immune activation type patients can obtain benefits from immunological therapy. Prognosis of the different immune subtypes is further analyzed, immune type patients are found better than nonimmune type patients in the prognosis, after the immune type patients are divided into the immune activation type and the immunodepletion type, the prognosis of the immune activation type patients is the best.

Description

technical field [0001] The invention relates to a marker for predicting the curative effect of head and neck tumor immunotherapy and its application. Background technique [0002] Head and neck cancer is the sixth most common malignant tumor in the world, and its morbidity / mortality rate ranks in the top ten of all tumors. Head and neck squamous cell carcinoma is the most common type of head and neck cancer, accounting for about 90% of neck tumors. According to different clinical stages, the current treatment methods for head and neck tumors are also different, mainly based on surgery or radiotherapy, supplemented by chemotherapy, targeted therapy and other multidisciplinary comprehensive treatments. With the innovation of treatment methods and the implementation of standardized treatment, the survival rate and quality of life of patients with early head and neck cancer have been improved, but the prognosis of patients with advanced head and neck cancer is still poor. Ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/106C12Q2600/118
Inventor 马骏陈雨沛柳娜王雅琴吕佳蔚黎映琴孙颖唐玲珑毛燕萍陈磊周冠群郭蕊
Owner SUN YAT SEN UNIV CANCER CENT
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