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Flavonoid control extract and its preparation method and use

An extract and flavonoid technology, which is applied in the field of Citrus aurantium or Citrus aurantium flavonoids control extract, can solve the problems of low transfer rate and large loss of flavonoid components, and achieve the effect of high transfer rate, stable content and high content

Active Publication Date: 2020-11-06
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The loss of flavonoid components in the above method is relatively large, and the transfer rate is low

Method used

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  • Flavonoid control extract and its preparation method and use
  • Flavonoid control extract and its preparation method and use
  • Flavonoid control extract and its preparation method and use

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preparation example Construction

[0027] The preparation method of the Fructus Aurantii Fructus or Fructus Fructus flavonoids control extract of the present invention comprises the following steps: 1) extraction step; 2) separation step; 3) macroporous resin purification step; 4) mixing step.

[0028]

[0029] In the extraction step of the present invention, extracting Fructus Fructus Fructus Fructus Fructus or Fructus Fructus Aurantii with ethanol aqueous solution containing ammonia as a solvent to obtain an alcohol extract; the alcohol extract is concentrated and dried to obtain an alcohol extract. The ethanol concentration of the ammonia-containing ethanol aqueous solution is 50-80vol%, preferably 60-75vol%, more preferably 70-75vol%; the content of ammonia is 0.07-0.2wt%, preferably 0.1-0.18wt%, more preferably Preferably it is 0.12 to 0.15 wt%. According to a preferred embodiment of the present invention, the ethanol concentration of the ammonia-containing ethanol aqueous solution is 70-75 vol%, and the...

Embodiment 1

[0072] The preparation of embodiment 1-alcoholic extract

[0073] Ammonia-containing ethanol aqueous solution is used as a solvent, and the heating and reflux extraction method is used to extract Fructus Fructus Fructus Fructus Aurantii. The number of extractions is 2 times, and the amount of solvent used for each extraction is 8 times the weight of Fructus Fructus Fructus Fructus Aurantii, and the extraction time is 1.5 hours each time to obtain an alcoholic extract; The alcohol extract was concentrated under reduced pressure and dried in vacuo to obtain the alcohol extract. Wherein the content of ammonia in the aqueous ethanol solution containing ammonia is 0.14wt%, and the concentration of ethanol is 70vol%.

Embodiment 2

[0074] The preparation of embodiment 2-alcoholic extract

[0075] Ammonia-containing ethanol aqueous solution is used as a solvent, and the heating and reflux extraction method is used to extract Fructus Fructus Fructus Fructus Aurantii. The number of extractions is 2 times, and the amount of solvent used for each extraction is 8 times the weight of Fructus Fructus Fructus Fructus Aurantii, and the extraction time is 1.5 hours each time to obtain an alcoholic extract; The alcohol extract was concentrated under reduced pressure and dried in vacuo to obtain the alcohol extract. Wherein the content of ammonia in the aqueous ethanol solution containing ammonia is 0.14wt%, and the concentration of ethanol is 50vol%.

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Abstract

The invention discloses a flavonoid reference extract, and a preparation method and application thereof. The preparation method includes the following steps: (1) extracting fructus aurantii immaturusor fructus aurantii by ammonia-containing ethanol water as a solvent to obtain an alcohol extract; (2) dispersing the alcohol extract in water, performing solid-liquid separation to obtain clear liquid and insoluble substances, and drying the insoluble substances to obtain first flavonoid extract; (3) purifying the clear liquid by macroporous adsorption resin columns to obtain second flavonoid extract; (4) evenly mixing the first flavonoid extract with the second flavonoid extract to obtain the flavonoid reference extract. The extraction method provided by the invention has the advantages of small loss of flavonoid components and high transfer rate.

Description

technical field [0001] The invention relates to a flavonoid control extract, in particular to a flavonoid control extract of citrus aurantium or citrus aurantium, and also relates to its preparation method and use. Background technique [0002] Chinese medicine reference extracts refer to traditional Chinese medicine extracts with clear main chemical components and content, good stability and high purity. The proportion of each chemical component is relatively fixed, and the content of index components has been calibrated, which can realize the qualitative analysis of multiple components at the same time And quantitative analysis, its price is usually lower than the sum of multiple component monomer reference substances. Therefore, the material cost of the traditional Chinese medicine control extract is lower, and the detection procedure is simplified, which can greatly save the detection cost. [0003] Citrus aurantium is the dry young fruit of Citrus aurantium L. and its ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H1/08C07H17/07
Inventor 刘斌姜艳艳杨丽丽张永文
Owner BEIJING UNIV OF CHINESE MEDICINE
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