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Non-invasive serological scoring model for hepatic fibrosis and design method thereof

A non-invasive technology for liver fibrosis, applied in the medical field, can solve problems such as unclear role and inability to meet clinical needs in diagnostic performance, and achieve the effects of simple use, reduced chance of invasive examination, and reduced risk and burden

Inactive Publication Date: 2019-03-15
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, their role in differentiating the degree of fibrosis and reflecting the progression of fibrosis is not yet clear, and the diagnostic performance does not meet the clinical needs

Method used

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  • Non-invasive serological scoring model for hepatic fibrosis and design method thereof
  • Non-invasive serological scoring model for hepatic fibrosis and design method thereof
  • Non-invasive serological scoring model for hepatic fibrosis and design method thereof

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Experimental program
Comparison scheme
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Embodiment Construction

[0027] The present invention will be described in further detail below.

[0028] The non-invasive serological scoring method for liver fibrosis of the present invention is as follows:

[0029] 1. Research object

[0030] A total of 420 patients with chronic hepatitis B in a tertiary hospital from July 2016 to March 2018 (meeting the inclusion and exclusion criteria) were collected. 420 patients with chronic hepatitis B were divided into 2 groups, namely the training group and the verification group, of which 252 cases were in the training group (July 2016 to July 2017), and 168 cases were in the verification group (July 2017 to 2018 3 months), that is, the training group and the verification group are patients from different time periods.

[0031] 2. Research parameters

[0032] 420 patients with chronic hepatitis B were measured and recorded clinical laboratory parameters, including age, gender, alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelet cou...

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Abstract

The invention relates to a non-invasive serological scoring model for hepatic fibrosis and a design method thereof. The model includes an input module, a processing module and an output module. The input module receives three independent predictors including blood platelet count, laminin and procollagen type 3. The processing module is connected with the input module and evaluates the situation ofhepatic fibrosis based on the independent predictors. The output module is connected with the processing module and outputs the score finally obtained by the module. The model can more accurately evaluate the situation of severe hepatic fibrosis for patients with chronic hepatitis. Compared with other models, the model only involves the three independent predictors including PLT, LN and PIIINP.The contained serological indicators are fewer, the accuracy and the practicability are higher, the model is more concise to use, popularization in clinical treatment and primary hospitals is facilitated, the probability of invasive examination is thus reduced, and the risk and burden of the patients are reduced.

Description

technical field [0001] The invention relates to the medical field, in particular to a non-invasive serological scoring model for liver fibrosis and a design method thereof. Background technique [0002] Chronic hepatitis has been shown to lead to liver fibrosis, which may eventually develop into cirrhosis, end-stage liver disease and liver cancer. Liver fibrosis is a dynamic pathophysiological process, and the correct assessment of the degree of liver fibrosis can affect clinical treatment strategies. Early diagnosis and effective antiviral treatment can significantly improve the prognosis of chronic hepatitis B patients with histologically moderate to severe fibrosis or liver cirrhosis, and can also improve the quality of life of patients. Preventing liver fibrosis from progressing to liver cirrhosis and liver cancer is the key to treating chronic liver diseases, and it is necessary to regularly detect the degree of liver fibrosis. Therefore, finding an inexpensive and mo...

Claims

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Application Information

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IPC IPC(8): G16H50/30
CPCG16H50/30
Inventor 胡波崇雨田龚娇陈亚琼
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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