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Application of 3-acetylaminocoumarin in the preparation of medicines for treating or preventing hyperuricemia and kidney damage

A technology of hyperuricemia and acetamido, which is applied in the direction of drug combinations, urinary system diseases, and active ingredients of heterocyclic compounds, and can solve problems such as liver toxicity, damage, and severe allergic reactions to the kidneys

Active Publication Date: 2021-04-23
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these first-line uric acid-lowering drugs have certain side effects. Allopurinol can cause severe allergic reactions and kidney damage, while benzbromarone has liver toxicity.

Method used

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  • Application of 3-acetylaminocoumarin in the preparation of medicines for treating or preventing hyperuricemia and kidney damage
  • Application of 3-acetylaminocoumarin in the preparation of medicines for treating or preventing hyperuricemia and kidney damage
  • Application of 3-acetylaminocoumarin in the preparation of medicines for treating or preventing hyperuricemia and kidney damage

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Experiments were carried out on the protective effect of drugs prepared from 3-acetamidocoumarin on hyperuricemia and the resulting kidney damage, wherein the animals were divided into groups: 30 male ICR mice, 18-22g, 6 in each group, divided into Sham in the control group, Sham-3A in the blank administration group, Model in the model group, and 3A in the administration group. At the same time, the administration group 3A was subdivided into 3A-HD and 3A-MD according to the administration of 3-acetylaminocoumarin , 3A-LD, the doses were 50mg / Kg / d, 10mg / Kg / d, 2mg / Kg / d for experiments.

[0026] The method of administration was intragastric administration, administered once a day, for three consecutive weeks, and started modeling after one week of administration. The model was made by intraperitoneal injection, oxonate potassium and hypoxanthine were given 300 mg / kg each, and the control group was given solvent saline. After the last administration, the eyeballs were rem...

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Abstract

The invention provides the application of 3-acetylaminocoumarin in the preparation of medicine for treating or preventing hyperuricemia, and also provides the application of 3-acetamidocoumarin in the preparation of medicine for treating or preventing kidney damage. The present invention induces hyperuricemia in mice by potassium oxonate and hypoxanthine, and 5-100 mg / kg / d of 3-acetamidocoumarin is orally administered, wherein the blood uric acid level of the mice in the model group is significantly increased, and the kidney The damage was significant; the blood uric acid level of mice in the administration group decreased significantly, and the kidney protection effect was remarkable.

Description

technical field [0001] The invention belongs to the field of medicines, and particularly relates to the application of 3-acetylaminocoumarin in the preparation of medicines for treating or preventing hyperuricemia and hyperuric acid kidney damage. Background technique [0002] With the improvement of people's living standards, the intake of high-purine foods increases, and purine metabolism is prone to disorder, which can easily increase blood uric acid and cause hyperuricemia (hyperuricemia). According to the report of the China Chronic Kidney Disease Epidemiological Survey Collaborative Group, the prevalence rate of hyperuricemia in Chinese adults was 8.4% from 2009 to 2010. Based on this, it is estimated that there are nearly 93 million hyperuricemia among Chinese people over the age of 18 disease patients, has reached the level of Western developed countries. Hyperuricemia is not only closely related to the pathogenesis of gout, but also closely related to obesity, hype...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/37A61P19/06A61P13/12
CPCA61K31/37A61P13/12A61P19/06
Inventor 周虹谢正伟杨宝学王一鸣王亮李海涛
Owner PEKING UNIV
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