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A kind of preparation method of the health food of coenzyme Q10 liposome

A liposome and coenzyme technology, applied in liposome delivery, food science and other directions, can solve the problems of low encapsulation rate, small particle size, particle coagulation, etc., to improve the encapsulation rate and improve the coagulation problem. Effect

Active Publication Date: 2022-02-08
JIANGSU ALAND NOURISHMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a health food of coenzyme Q10 liposome and its preparation method. The coenzyme Q10 liposome prepared by the present invention can improve the bioavailability of coenzyme Q10, and solve the problem of high-concentration coenzyme Q10 liposome by optimizing the preparation method. During the preparation of plastids, there are problems such as low encapsulation efficiency, too small particle size, and particle aggregation during storage.

Method used

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  • A kind of preparation method of the health food of coenzyme Q10 liposome
  • A kind of preparation method of the health food of coenzyme Q10 liposome
  • A kind of preparation method of the health food of coenzyme Q10 liposome

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Coenzyme Q10 liposomes prepared from soybean lecithin with different phosphatidylcholine contents

[0031] 1 Experimental materials

[0032]

[0033] 2 Experimental methods

[0034] 1) Preparation of coenzyme Q10 liposomes

[0035] Dissolve 1.5g of soybean lecithin with different phosphatidylcholine content, 0.36g of cholesterol, 800mg of coenzyme Q10, 400mg of Tween-80 and 80mg of VE acetate in absolute ethanol, heat to dissolve at 60°C, and decompress in a water bath at 45°C Evaporate to form a smooth film, add 20mL of water phase medium PBS (pH=7.2) and 30-40 pieces of 4-5mm glass beads, hydrate the film in a water bath at 45°C to obtain an emulsified liquid, and ultrasonicate the emulsified liquid in an ice bath with an ultrasonic power of 400W, working time is 5min (working 1s / intermittent 1s), through ultrasonic emulsion to obtain coenzyme Q10 liposomes with a particle size of nanometer.

[0036] 2) Determination of particle size and polydispersity index PDI...

Embodiment 2

[0041] The coenzyme Q10 liposome prepared by embodiment 2 soybean lecithin

[0042] 1 Experimental materials

[0043]

[0044] 2 Experimental methods

[0045] 1) Preparation of coenzyme Q10 liposomes

[0046] Dissolve 1.5g of soybean lecithin (90% phosphatidylcholine content), 0.36g of cholesterol, 800mg of coenzyme Q10, 400mg of Tween-80 and 80mg of VE acetate in absolute ethanol, heat at 60°C to dissolve, and dissolve at 45°C Evaporate under reduced pressure in a water bath to form a smooth film, add 20mL of water phase medium PBS (pH=7.2) and 30-40 glass beads with a particle diameter of 4-5mm, hydrate the film in a water bath at 45°C to obtain an emulsified liquid, and place the emulsified liquid in an ice bath Ultrasound, the ultrasonic power is 400W, the working time is 5min (working 1s / intermittent 1s), and the coenzyme Q10 liposome with a particle size of nanometer is obtained through ultrasonic emulsion.

[0047] 2) Determination of particle size and polydispersit...

Embodiment 3

[0049] The coenzyme Q10 liposome prepared by embodiment 3 egg yolk lecithin

[0050] 1 Experimental materials

[0051]

[0052] 2 Experimental methods

[0053] 1) Preparation of coenzyme Q10 liposomes

[0054] Dissolve 3.0g egg yolk lecithin (phosphatidylcholine content is 60%), 0.72g cholesterol, 800mg coenzyme Q10, 500mg Tween-80 and 300mg VE acetate in absolute ethanol, heat to 60°C to dissolve, 45°C Evaporate in a water bath under reduced pressure to form a smooth film, dry in vacuum at 60°C for 2 hours, add 40mg of surfactant PVP and 3% protective agent glycerin, add 20mL of water phase medium PBS (pH=7.2) and an appropriate amount of 4-5mm glass beads, 45°C The emulsified liquid was obtained by hydrating the film in a water bath, and the emulsified liquid was subjected to ultrasonication in an ice bath, the ultrasonic power was 500W, and the working time was 5min (working 1s / interval 1s), and the nano-sized coenzyme Q10 liposomes were obtained through the ultrasonic...

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Abstract

The invention belongs to the technical field of health food, and in particular relates to a health food of coenzyme Q10 liposome and a preparation method thereof. The coenzyme Q10 liposome is a liquid oral health product, coenzyme Q10, lecithin, cholesterol, Tween-80 and V E Acetate is heated and dissolved with ethanol, and evaporated under reduced pressure to form a smooth film; after vacuum drying, polyvinylpyrrolidone and glycerin are added, and an aqueous medium is added to hydrate the film to obtain an emulsified liquid, and ultrasonic emulsion is obtained to obtain nano-scale coenzyme Q10 lipid Plastids; the concentration of coenzyme Q10 can reach 30-40mg / mL. By encapsulating the coenzyme Q10 in liposomes, the present invention can solve the disadvantage of unstable coenzyme Q10 liquid oral solution, and can enhance the bioavailability of the coenzyme Q10 in the body to realize the passive targeting of the coenzyme Q10. The prepared coenzyme Q10 liposome has the functions of improving human immunity, enhancing anti-oxidation and delaying aging.

Description

technical field [0001] The invention belongs to the technical field of health food, and in particular relates to a health food of coenzyme Q10 liposome and a preparation method thereof. Background technique [0002] Coenzyme Q10, also known as ubiquinone, exists in the mitochondria of any cell and plays a very important role in the production and delivery of human cell energy. Coenzyme Q10 is an international research hotspot in recent years. It is one of the important biochemical coenzymes in human cells. It has multiple functions such as enhancing immunity, anti-oxidation, assisting in lowering blood lipids, and relieving physical fatigue. In the mitochondrial respiratory chain of cells, coenzyme Q10 receives hydrogen delivered by the flavoprotein and iron-sulfur protein complex and is reduced to hydroquinone, which can then transfer electrons to the cytochrome system and leave protons in the environment , and itself is oxidized to quinone-type coenzymes. As a hydrogen d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A23L33/00
CPCA23L33/00
Inventor 张国栋林琳夏旭东崔海英沙香张兴
Owner JIANGSU ALAND NOURISHMENT
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