Polylactic acid microsphere and preparation method and application thereof

Abstract

The invention discloses a polylactic acid microsphere and a preparation method and application thereof. The grain size of the microsphere is between 100 mu m and 1000 mu m, preferably between 100 mu mand 300 mu m, between 300 mu m and 500 mu m, between 500 mu m and 700 mu m or between 700 mu m and 1000 mu m, the microsphere is a regular sphere, and the surface and interior of the microsphere areprovided with holes. Because the polylactic acid microsphere is a regular sphere, by adjusting the variety and molecular weight of polylactic acid, the degradation time of the microsphere can be controlled, which is favorable for the determination of the degradation time of the microsphere in the body and the recanalization time of blood vessels in clinical application. The preparation method disclosed by the invention can cut out drops with small grain size under low flow velocity, moreover, the stability of oil-phase fluid is good, the drops do not have tails after coagulant is added, the sphericity of the solidified microsphere is good, and the effect is best. Moreover, by forming the holes in the surface and interior of the microsphere, solvent can be conveniently volatilized, so thatthe amount of remaining solvent is small, meeting the standard of the pharmacopoeia.

Description

technical field [0001] The invention relates to the technical fields of polymer materials and biomedical engineering, in particular to a polylactic acid microsphere and its preparation method and application. Background technique [0002] Embolization therapy is a major means of intervention in the field of oncology. Tumor embolization therapy is aimed at blocking tumor nutrient vessels or controlling bleeding disorders. In the past two decades, due to the emergence of microcatheters and the development of new embolic agents, the clinical application of tumor embolization has shown a clear upward trend. Most notably, the use of selective embolization is critical for tumor therapy based on individual pathology, anatomy, and hemodynamic studies. At present, particle embolization agents are the main dosage forms for the treatment of liver tumors, especially arterial embolization (TAE) or chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). [0003] T...

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Problems solved by technology

When the level of organic solvent contained in the microspheres (generally 0.17%-0.6%) is higher than the safe value (the residual amount of dichloromethane in the Chinese Pharmacopoeia is ≤0.06%, and the residual amount of acetone is ≤0.5%), it will be harmful to the human body. Or the environment is harmful, but none of the above methods mentions the removal of residual organic solvents

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