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Method, kit and system for verifying blood serology agglutination intensity judgment capability

A proficiency verification and serological technology, applied in scientific instruments, biological testing, material inspection products, etc., can solve the problems of unseen blood type serological agglutination strength kits and systems

Inactive Publication Date: 2019-01-18
SHANGHAI BLOOD CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no verification method, kit and system for the ability to determine the strength of blood group serological agglutination of the present invention.

Method used

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  • Method, kit and system for verifying blood serology agglutination intensity judgment capability
  • Method, kit and system for verifying blood serology agglutination intensity judgment capability
  • Method, kit and system for verifying blood serology agglutination intensity judgment capability

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Experimental program
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Effect test

Embodiment 1

[0047] The method of the present invention for preparing red blood cells with different agglutination intensities utilizes the formation of different quantitative red blood cell antibodies that bind to a certain number of red blood cells to achieve a sequence of strong to weak agglutination strength from 4+ to negative, which is used to verify that the laboratory is relatively The ability to judge the intensity of the reaction. By analyzing the test results of participating laboratories, the ability of the participating laboratories to detect antibodies with different reaction strengths can be accurately evaluated.

[0048] The present invention has been tried out in nearly 200 laboratories in China. From the feedback result analysis, the method can effectively evaluate the laboratory's ability to determine the agglutination intensity, which is of critical significance. Details are as follows:

[0049] 1. Specimen preparation for determination of agglutination strength

[0050] The...

Embodiment 2

[0064] See figure 1 , figure 1 It is a flowchart of the method for verifying the ability to determine the agglutination strength of blood group serology of the present invention. It includes the following steps:

[0065] 1. The evaluator delivers 8 different concentrations of blood group antibody-containing whole plasma products and corresponding red blood cells and instructions to the subject. The instructions record the requirement to react 8 blood group antibodies with corresponding red blood cells and determine each The aggregation strength of the reaction.

[0066] 2. Subjects receive 8 different concentrations of whole plasma products containing blood group antibodies, as well as corresponding red blood cells and instructions.

[0067] 3. The subject reacted 8 different concentrations of whole plasma products containing blood group antibodies with corresponding red blood cells according to the instructions, and judged the agglutination intensity of each reaction, and fed back ...

Embodiment 3

[0071] A blood group serological agglutination strength determination test kit, including:

[0072] 8 different concentrations of whole plasma products containing blood group antibodies;

[0073] Corresponding red blood cells;

[0074] Instructions: Record the need to react 8 different concentrations of whole plasma products containing blood group antibodies with the corresponding red blood cells, and record the detection methods and results.

[0075] Among them, 8 different concentrations of whole plasma products containing blood group antibodies and the corresponding red blood cell reaction have agglutination intensities ranging from 4+ to negative, with the strongest being 4+ and the weakest being negative; and 8 different concentrations of whole blood group antibody-containing whole The agglutination intensity of the plasma product and the corresponding red blood cell reaction is known to the kit provider.

[0076] Wherein, the blood group antibody is selected from any one or more ...

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Abstract

The invention relates to a method, kit and system for verifying blood serology agglutination intensity judgment capability. The method comprises the steps of delivering eight blood antibodies with different concentrations and known standard agglutination intensity and corresponding antigen-containing red blood cells such as anti-A whole plasma product, Ac and specification to a subject by an estimator; judging agglutination intensity of each sample and the Ac by the subject according to the specification, and delivering a method and a result to the estimator; and comprehensively judging the obtained blood serology agglutination intensity judgment capability of the subject by the estimator according to a method type used by the subject, the result and the standard agglutination intensity. The kit comprises the eight blood antibodies with different concentration and the corresponding antigen-containing red blood cells such as the anti-A whole plasma product, the Ac and the specification.The system comprises the kit, an estimation end, an acceptance end and a verification platform. The method can be effectively used for estimating the blood serology agglutination intensity judgment capability of immunohematology such as relevant laboratory or a person.

Description

Technical field [0001] The invention relates to the field of blood testing, and in particular to a method, a kit and a system for verifying the ability to determine agglutination strength of blood group serology. Background technique [0002] Immunohematology-related laboratories or professional technicians should have sufficient ability to determine the agglutination intensity of blood group serology to ensure the accuracy of the results to meet the needs of clinical or scientific research. At present, there is a lack of quality control products and methods for evaluating the ability to determine the agglutination strength of different blood groups in serology. Existing similar quality control products, which are "internal quality control products" issued by industries, organizations or laboratories, are composed of one or several human blood samples, and all results are determined as positive or negative based on the agglutination intensity for reporting Quality assessment res...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6854
Inventor 向东金沙沈伟
Owner SHANGHAI BLOOD CENT
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