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A kind of lung cancer marker anti-psip1 autoantibody and its application

A technology of autoantibodies and markers, applied in the field of biomedical detection, can solve problems such as unsatisfactory tumor markers

Active Publication Date: 2021-04-23
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to overcome the problem of unsatisfactory existing tumor markers of lung cancer, aiming to provide a new application of anti-PSIP1 autoantibodies, in improving the sensitivity, specificity and accuracy of the diagnosis of metastatic lung cancer

Method used

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  • A kind of lung cancer marker anti-psip1 autoantibody and its application
  • A kind of lung cancer marker anti-psip1 autoantibody and its application
  • A kind of lung cancer marker anti-psip1 autoantibody and its application

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Embodiment 1

[0028] 1. Collection of serum samples

[0029] A total of 1379 cases of research objects were included in the present invention, and were divided into a test group and a verification group. The test group was used to screen the indicators with high diagnostic value for lung cancer, and the verification group performed large-scale serological verification on these indicators. The serum of 184 lung cancer patients included in the test group came from lung cancer patients in the First Affiliated Hospital of Zhengzhou University from 2016 to 2017. The sera of 446 lung cancer patients included in the verification group were from lung cancer patients who were treated in the First Affiliated Hospital of Zhengzhou University from 2013 to 2014. All cases were confirmed by histopathology without any operation, radiotherapy and chemotherapy. The 184 normal controls in the test group and the 446 normal controls in the verification group were all from healthy persons undergoing physical exa...

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Abstract

The invention belongs to the technical field of biomedical detection, and in particular relates to a lung cancer marker anti-PSIP1 autoantibody and its application. The invention discloses a lung cancer marker, and the lung cancer marker is an anti-PSIP1 autoantibody. The present invention also provides the application of the above-mentioned lung cancer markers in the preparation of a lung cancer detection kit. The invention provides a serum biomarker for clinical detection of lung cancer with simple operation, low cost, high accuracy and no trauma. The present invention finds that the application of ELISA method to detect serum anti-PSIP1 autoantibodies can more accurately distinguish lung cancer patients from normal people and patients with benign lung diseases, and can be used for the detection of metastatic lung cancer. In this context, the convenient, fast and effective marker for detecting lung cancer patients and the reagent kit for preparing the marker for lung cancer detection are provided, which can be used for clinical early diagnosis of lung cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a lung cancer marker anti-PSIP1 autoantibody and application thereof. Background technique [0002] Lung cancer is the malignant tumor with the highest morbidity and mortality in China and in the world. The clinical manifestations of lung cancer are complex and diverse. The manifestations of early lung cancer are hidden and diverse, and the clinical features and signs are not obvious. They only manifest as non-specific symptoms such as cough, expectoration, chest pain, fever, and physical decline. late. According to clinical data, nearly 60% of patients are already in the advanced stage of lung cancer when they see a doctor. The 5-year survival rate of advanced lung cancer is only about 16%, while the 5-year survival rate of early stage lung cancer (stage I) can be as high as 70%. It can be seen that early detection and early diagnosis of lung cancer a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 代丽萍刘红春王鹏王婷婷裴露蒋迪
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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