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Medicinal composition for treating diabetes, preparation method and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of limited therapeutic effect and difficulty in fully exerting the effect, and achieve the effect of improving the effect of lowering blood sugar

Active Publication Date: 2019-12-03
吉林浩泰健康产业发展股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned patents, only the combination of porcine pancreas and traditional Chinese medicine is combined, and the main active factors in porcine pancreas are inhibited, making it difficult to fully exert their effects, and the final therapeutic effect is still limited.

Method used

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  • Medicinal composition for treating diabetes, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The composition of the hypoglycemic drug composition: 10 parts of astragalus, 12 parts of yam, 8 parts of Codonopsis pilosula, 9 parts of medlar, 5 parts of Poria cocos, 13 parts of corn silk, 7 parts of peach kernel, 13 parts of porcine pancreas, and 7 parts of bitter gourd polypeptide.

[0047] The preparation method of described hypoglycemic pharmaceutical composition comprises the following steps:

[0048] (1) Add astragalus, Codonopsis pilosula, Lycium barbarum, corn silk, and peach kernel to enzymatic hydrolysis, add water, extract at 50°C for 3 hours, concentrate under reduced pressure to obtain mixture 1, and set aside;

[0049] (2) Chinese yam and Poria cocos are pulverized and passed through an 80-mesh sieve to obtain mixture 2, which is set aside;

[0050] (3) Fresh porcine pancreas minus excess adipose tissue was washed with normal saline, mashed, soaked in acetic acid for 15 hours and then freeze-dried and pulverized to obtain porcine pancreas powder for su...

Embodiment 2

[0054] The composition of the hypoglycemic drug composition: 12 parts of astragalus, 15 parts of Chinese yam, 11 parts of Codonopsis pilosula, 12 parts of medlar, 6 parts of poria cocos, 14 parts of corn silk, 8 parts of peach kernel, 14 parts of porcine pancreas, and 8 parts of bitter gourd polypeptide.

[0055] The preparation method of described hypoglycemic pharmaceutical composition comprises the following steps:

[0056] (1) Add astragalus, Codonopsis pilosula, Lycium barbarum, corn silk, and peach kernels to enzymatic hydrolysis, add water, extract at 55°C for 3 hours, concentrate under reduced pressure to obtain mixture 1, and set aside;

[0057] (2) Chinese yam and Poria cocos are pulverized and passed through a 100-mesh sieve to obtain mixture 2, which is set aside;

[0058] (3) Fresh porcine pancreas minus excess adipose tissue, washed with normal saline, mashed, soaked in acetic acid for 17 hours and then freeze-dried and pulverized to obtain porcine pancreas powde...

Embodiment 3

[0062] The hypoglycemic drug composition consists of 9 parts of astragalus, 10 parts of yam, 7 parts of Codonopsis pilosula, 8 parts of medlar, 3 parts of poria, 10 parts of corn silk, 5 parts of peach kernel, 10 parts of porcine pancreas, and 5 parts of bitter gourd polypeptide.

[0063] The preparation method of described hypoglycemic pharmaceutical composition comprises the following steps:

[0064] (1) Add astragalus, Codonopsis pilosula, Lycium barbarum, corn silk, and peach kernels to enzymatic hydrolysis, add water and extract at 50°C for 2 hours, concentrate under reduced pressure to obtain mixture 1, and set aside;

[0065] (2) Chinese yam and Poria cocos are pulverized and passed through an 80-mesh sieve to obtain mixture 2, which is set aside;

[0066] (3) Fresh porcine pancreas minus excess adipose tissue was washed with physiological saline, mashed, soaked in acetic acid for 18 hours, and then freeze-dried and pulverized to obtain porcine pancreas powder for subse...

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Abstract

The invention provides a plant peptide extraction method and an application thereof and particularly relates to a bitter gourd peptide extraction method. The method comprises the steps as follows: a bitter gourd aqueous solution is purified with a microporous filtration membrane and a roll type ultrafiltration membrane, and a purified trapped solution is subjected to concentration, dialysis and drying to obtain bitter gourd polypeptide. The content of the prepared bitter gourd polypeptide reaches 30% or above, the impurity removal effect is obvious, and the efficacy of the bitter gourd peptidein reducing blood sugar can be significantly improved.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a pharmaceutical composition and its preparation method and application, in particular to a pharmaceutical composition for treating diabetes and its preparation method and application. Background technique [0002] In recent years, diabetes has become one of the three major chronic non-communicable diseases that threaten human health in the world. The fifth edition of the International Diabetes Federation pointed out that there are more than 92.4 million people with diabetes in China aged 20-79, accounting for about 1 / 4 of the total number of diabetes patients in the world. Diabetes has become a major killer that threatens human health. my country has carried out six epidemiological surveys of diabetes: in 1980, the diabetes survey of 300,000 people found that the prevalence rate was only 0.67%; in 1994, the second diabetes survey involving about 210,000 people in 19 provinces found The pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K1/14C07K1/34A61K38/16A61P3/10A61K35/39
CPCA61K35/39A61K36/076A61K36/344A61K36/481A61K36/736A61K36/815A61K36/8945A61K36/899A61K38/168A61P3/10C07K1/145C07K1/34A61K2300/00
Inventor 李雪殷金龙殷金玲李男男
Owner 吉林浩泰健康产业发展股份有限公司
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