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Method and DNA methylation marker for predicting calf muscle dimension decline risk in weightless muscle atrophy

A technology of methylation and muscular atrophy, applied in the field of physiology

Inactive Publication Date: 2018-12-21
SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the muscle atrophy caused by long-term space flight also poses challenges for astronauts to re-adapt to gravity after returning to the ground.

Method used

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  • Method and DNA methylation marker for predicting calf muscle dimension decline risk in weightless muscle atrophy
  • Method and DNA methylation marker for predicting calf muscle dimension decline risk in weightless muscle atrophy
  • Method and DNA methylation marker for predicting calf muscle dimension decline risk in weightless muscle atrophy

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Experimental program
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Effect test

Embodiment 1

[0046] 1. -6-degree head-down bed rest simulates weightlessness model

[0047] (1) Volunteer

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Abstract

The invention provides a DNA methylation marker for predicting the calf muscle dimension decline risk in weightless muscle atrophy. The DNA methylation marker comprises one or more of the following genes, and site annotation information thereof is shown in Table 3. The invention further provides a corresponding detection method. Excavation of the blood cell DNA methylation level and the calf muscle dimension finds that individual difference in human calf muscle dimension decline after weightlessness can be predicted through detection of the blood cell DNA methylation level, so that an individual which is more tolerant to a weightless condition is screened or calf muscle dimension change is scientifically researched. The invention provides a DNA methylation site set having a function of predicting the human calf muscle dimension decline risk after weightlessness.

Description

technical field [0001] The invention belongs to the technical field of physiology, and relates to physiological changes after a period of time under weightless environmental conditions, and in particular to a method and a DNA methylation marker for predicting the risk of calf muscle dimension decline in weightless muscle atrophy. Background technique [0002] Weightlessness muscular atrophy is a degenerative change of human muscles caused by the environment of weightlessness, and it is one of the important health risks that astronauts need to face in the medium and long-term environment of weightlessness. With the continuous development of manned space exploration, astronauts spend more time in orbit, and the impact of muscle atrophy on human health and on-orbit operation ability has become increasingly prominent. Under the condition of weightlessness in space, the muscle groups used by the human body are different from the environmental conditions of ground gravity. Becaus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/154
Inventor 梁峰吉熊江辉陈晓萍李莹辉刘红菊卢亮元艳宏曲丽娜陈善广
Owner SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
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