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Method for resisting against heavy metal Cd toxicity on basis of ZnO/GO composite nanomaterial

A technology of composite nanomaterials and heavy metals, which is applied in the field of antagonizing heavy metal toxicity materials, can solve problems such as limited antagonism ability, and achieve the effects of improved biological safety, simple and fast processing methods, and excellent antagonism effect.

Active Publication Date: 2018-12-07
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, since ZnO nanomaterials also have certain toxic effects, and heavy metal Cd exerts toxic effects through multiple mechanisms and multiple pathways, the antagonism of heavy metal Cd toxicity by a single ZnO nanomaterial is still very limited. of

Method used

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  • Method for resisting against heavy metal Cd toxicity on basis of ZnO/GO composite nanomaterial
  • Method for resisting against heavy metal Cd toxicity on basis of ZnO/GO composite nanomaterial
  • Method for resisting against heavy metal Cd toxicity on basis of ZnO/GO composite nanomaterial

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Effect test

Embodiment 1

[0047] A method for antagonizing heavy metal Cd toxicity based on ZnO / GO composite nanomaterials, comprising the following steps:

[0048] Step 1, the synthesis of ZnO / GO composite nanomaterial, its synthetic method comprises the following steps:

[0049] ① Weigh 0.55g of zinc acetate and dissolve in 50mL of absolute ethanol, stir vigorously at 80°C for 20min;

[0050] ②Weigh 0.2g of lithium hydroxide and dissolve in 20mL of absolute ethanol;

[0051] ③Add the dissolved lithium hydroxide ethanol solution to 30mL 2mg / mL GO dispersion;

[0052] ④ After the reaction of the zinc acetate solution in step ① is complete, when the temperature drops to 50°C, add the mixture of lithium hydroxide and GO into the zinc acetate solution, and stir for 40 minutes;

[0053] ⑤After the reaction, add n-hexane with twice the volume of the mixture, and let stand overnight at 4°C;

[0054] ⑥ Discard the supernatant by centrifugation, wash the materials with absolute ethanol and ultrapure water, ...

Embodiment 2

[0061] A method for antagonizing heavy metal Cd toxicity based on ZnO / GO composite nanomaterials, comprising the following steps:

[0062] Step 1, the synthesis of ZnO / GO composite nanomaterial, its synthetic method comprises the following steps:

[0063] ① Weigh 0.75g of zinc acetate and dissolve in 55mL of absolute ethanol, stir vigorously at 85°C for 25min;

[0064] ② Weigh 0.25g of lithium hydroxide and dissolve in 25mL of absolute ethanol;

[0065] ③ Add the dissolved lithium hydroxide ethanol solution to 35mL 2mg / mL GO dispersion;

[0066] ④ After the reaction of the zinc acetate solution in step ① is complete, when the temperature drops to 50°C, add the mixture of lithium hydroxide and GO into the zinc acetate solution, and stir for 45 minutes;

[0067] ⑤After the reaction is finished, add n-hexane with twice the volume of the mixture, and let stand overnight at 5°C;

[0068] ⑥ Discard the supernatant by centrifugation, wash the materials with absolute ethanol and ul...

Embodiment 3

[0075] A method for antagonizing heavy metal Cd toxicity based on ZnO / GO composite nanomaterials, comprising the following steps:

[0076] Step 1, the synthesis of ZnO / GO composite nanomaterial, its synthetic method comprises the following steps:

[0077] ① Weigh 0.25g of zinc acetate and dissolve it in 15mL of absolute ethanol, stir vigorously at 80°C for 15min;

[0078] ②Weigh 0.15g of lithium hydroxide and dissolve in 15mL of absolute ethanol;

[0079] ③ Add the dissolved lithium hydroxide ethanol solution to 25mL 2mg / mL GO dispersion;

[0080] ④ After the reaction of the zinc acetate solution in step ① is complete, when the temperature drops to 50°C, add the mixture of lithium hydroxide and GO into the zinc acetate solution, and stir for 35 minutes;

[0081] ⑤ After the reaction is over, add n-hexane with twice the volume of the mixture, and let stand overnight at 3°C;

[0082] ⑥ Discard the supernatant by centrifugation, wash the materials with absolute ethanol and ult...

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Abstract

The invention discloses a method for resisting against heavy metal Cd toxicity on the basis of a ZnO / GO composite nanomaterial. The method comprises the following steps: 1) compounding a ZnO / GO composite nanomaterial; 2) culturing model cells; 3) exposing the model cells in the ZnO / GO composite nanomaterial and heavy metal Cd; 4) detecting antagonistic efficiency. Through the technical scheme disclosed by the invention, the organism Cd poisoning can be specifically and effectively prevented and detoxified.

Description

technical field [0001] The invention relates to the field of materials for antagonizing heavy metal toxicity, in particular to a method for antagonizing heavy metal Cd toxicity based on ZnO / GO composite nanomaterials. Background technique [0002] Heavy metal Cd is widely used in many fields such as metal plating, battery preparation, paint, printing and pigment production. In addition, the mining, use and combustion of fossil fuels will also cause a large amount of heavy metal Cd to be released into the environment. Smoking, intake of air, food and water polluted by heavy metal Cd will cause heavy metal Cd to accumulate in the body. Since the half-life of heavy metal Cd in the organism is as long as 10-30 years, it is difficult to completely degrade and excrete the heavy metal Cd that enters the body. In addition, the toxicity concentration of heavy metal Cd is very low, and the accumulation of heavy metal Cd in the body caused by various acute or chronic exposures It wil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K47/04A61P39/02
CPCA61K33/30A61K47/02A61P39/02
Inventor 刘赟许安
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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