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High performance liquid chromatography for determining the content of compound Polygonum cuspidatum and Aminmin tablets

A high-performance liquid chromatography and component content technology, which is applied in the field of high-performance liquid chromatography for determining the component content of Compound Polygonum cuspidatum tablets, and can solve the problems of inability to ensure the safety and effectiveness of drugs and the like

Active Publication Date: 2021-06-22
广西壮族自治区食品药品检验所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its prescription consists of 296.3mg of Senecio dry paste, 1158mg of Polygonum cuspidatum dry paste, 100mg of acetaminophen, and 0.7mg of chlorpheniramine maleate in each tablet. Aminophenol is used for content determination, and the other three components have neither content detection methods nor unlimited regulations, which cannot ensure the safety and effectiveness of the drug
After investigation, there is no research report on the content determination of other components in Compound Polygonum cuspidatum Ammin Tablets

Method used

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  • High performance liquid chromatography for determining the content of compound Polygonum cuspidatum and Aminmin tablets
  • High performance liquid chromatography for determining the content of compound Polygonum cuspidatum and Aminmin tablets
  • High performance liquid chromatography for determining the content of compound Polygonum cuspidatum and Aminmin tablets

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Embodiment Construction

[0015] 1. Instruments and reagents

[0016] 1.1 Instruments Waters e2695 liquid chromatograph (with PDA detector); Milli-Q deionized water generator (Milli-Q company); Mettler-Toledo XS205DU electronic balance.

[0017] 1.2 Reagent acetaminophen; chlorpheniramine maleate; chlorogenic acid; Polydatin reference substances were purchased from China National Institutes for Food and Drug Control. Methanol and acetonitrile were chromatographic pure reagents, water was ultrapure water, and other reagents For analytical purity. The 6 batches of Compound Polygonum cuspidatum Ammonia-sensitive Tablets are all from manufacturer A (each tablet contains Senecio dry paste 23 mg, Polygonum cuspidatum dry paste 55 mg, acetaminophen 100 mg, and chlorpheniramine maleate 0.7 mg).

[0018] 2. Methods and results

[0019] 2.1 Chromatographic conditions Chromatographic column: Kromasil 100-5C 18 (5μm, 250×4.6mm); mobile phase: A: acetonitrile, B: 0.1% phosphoric acid solution, gradient elution p...

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Abstract

The invention discloses a high-performance liquid chromatography method for determining the component content of Compound Polygonum cuspidatum Ammonia Tablets, which adopts 50% methanol solution for ultrasonic extraction, uses acetonitrile-0.1% phosphoric acid solution as mobile phase, and Kromasil 100-5 C 18 Chromatographic column separation, ultraviolet detection wavelength is 222nm, 326nm. The method adopts high-performance liquid chromatography-ultraviolet spectroscopy dual-wavelength method to realize the simultaneous determination of two chemical components of paracetamol and chlorpheniramine maleate and the main components of Senecio dry paste, chlorogenic acid, and Polygonum cuspidatum dry paste. The content detection of polydatin, the main component, has the characteristics of rapid pretreatment, good separation between the four components and other components, and good accuracy. The invention provides a reference for better evaluating and controlling the quality of compound polygonum cuspidatum and ammonia-min tablets.

Description

technical field [0001] The invention belongs to the technical field of component content detection of compound polygonum cuspidatum and ammonia-sensitive tablets, and in particular relates to a high-performance liquid chromatography method for determining the component content of compound polygonum cuspidatum and ammonia-sensitive tablets. Background technique [0002] Compound Polygonum cuspidatum Ammin Tablets is an over-the-counter cold medicine compounded by Chinese and Western medicines. It is used for headache, fever, runny nose, pharyngitis, etc. caused by colds. Its prescription consists of 296.3mg of Senecio dry paste, 1158mg of Polygonum cuspidatum dry paste, 100mg of acetaminophen, and 0.7mg of chlorpheniramine maleate in each tablet. The content of aminophenol is measured, and the other three components have no content detection method and unlimited regulations, which cannot ensure the safety and effectiveness of the drug. After investigation, there is no resear...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/02G01N30/74
CPCG01N30/02G01N30/06G01N30/74
Inventor 邓鸣卢日刚朱健萍李智明杨娜曾庆花
Owner 广西壮族自治区食品药品检验所
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