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Application of petal-free sonneratia caseolaris fruit in preparation of drug for preventing and treating chemical liver injury

A technology of chemical liver injury and non-valve sea mulberry, which can be applied in the fields of drug combination, digestive system, pharmaceutical formula, etc., can solve the problem of less research on biological activity

Inactive Publication Date: 2018-10-30
GUANGDONG ACAD OF FORESTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few researches on the biological activity of Sangria apetalum fruit at home and abroad, and there is no report on the use of Sangria apetalum fruit to prevent or treat chemical liver injury

Method used

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  • Application of petal-free sonneratia caseolaris fruit in preparation of drug for preventing and treating chemical liver injury
  • Application of petal-free sonneratia caseolaris fruit in preparation of drug for preventing and treating chemical liver injury
  • Application of petal-free sonneratia caseolaris fruit in preparation of drug for preventing and treating chemical liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 (medicine preparation example)

[0013] 1. Preparation of water extract

[0014] Take the fruit of Sonneratia apetala, wash it with water to remove impurities, add 4 times the amount of water to decoct for 3 hours, filter the decoction, concentrate, and freeze-dry to obtain the water extract.

[0015] 2. Preparation of granules

[0016] Take 10g of the fruit water extract of Sangria apetala, add 50g of dextrin and 100g of powdered sugar, mix evenly, add an appropriate amount of water-based soft material, pass through a 14-mesh sieve, squeeze and granulate, then vacuum-dry at 60°C, and granulate to obtain Finished granules.

[0017] 3. Preparation of capsules

[0018] Take 8g of sea mulberry fruit water extract, sieve, add 15g of starch and mix evenly, and add 10% starch slurry 10ml to stir to make soft material, granulate through 80 mesh sieve, vacuum dry at 60°C, granulate, add hard Magnesium fatty acid 0.2g, mix homogeneously, pack into capsules to ob...

Embodiment 2

[0021] Embodiment 2 (effect example)

[0022] The medicines used in the low-dose group, middle-dose group and high-dose group described in this example are the aqueous extracts of the fruit of Sangria apetala prepared in Example 1. The drug used in the bifendate group in this example is 4,4'-dimethoxy-5,6,5',6'-dimethoxy-2,2'-biphenyldicarboxylic acid dimethyl Esters were purchased from Dalian Meilun Biotechnology Co., Ltd.

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Abstract

The invention relates to application of a petal-free sonneratia caseolaris fruit in the preparation of a drug for preventing and treating chemical liver injury. The petal-free sonneratia caseolaris fruit has relatively good effects on the treatment of liver injury caused by carbon tetrachloride, acetaminophen, antitumor drug cis-platinum, alcohol and heavy metal lead and therefore can be used forpreparing the drug for preventing and treating relevant liver injury.

Description

technical field [0001] The present invention relates to medical preparations, in particular to medicines containing undetermined structures from plants of the genus Sonneratia, which are suitable for preventing and treating chemical liver damage. Background technique [0002] The liver is the main metabolic organ in the human body, and liver injury can cause a variety of liver diseases, seriously affecting people's health, among which chemical liver injury, drug-induced liver injury and immune liver injury are more common. There are many causes of liver damage, including drugs, viral infections, alcoholism, radiation, heavy metal poisoning, etc. Some diseases are also accompanied by liver tissue damage, such as hepatitis, diabetes, blood stasis in the liver and cirrhosis of the liver. [0003] Chemical liver injury is liver damage caused by the entry of chemical hepatotoxic substances into the liver, including alcohol, environmental chemical toxins, and certain drugs. Long...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61K131/00
CPCA61K36/185A61P1/16
Inventor 蔡坚苏子仁张谦刘晶晶罗丹丹
Owner GUANGDONG ACAD OF FORESTRY
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