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Application of CXCR2 gene in heart-related diseases

A gene and heart technology, applied in the field of preparing diagnostic kits or therapeutic pharmaceutical compositions for heart-related diseases, can solve problems such as limiting clinical applications

Inactive Publication Date: 2018-10-16
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current pharmaceutical composition therapy has relatively large limitations, such as arrhythmia complications, treatment resistance and adverse outcomes, etc., which limit its clinical application to a certain extent.

Method used

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  • Application of CXCR2 gene in heart-related diseases
  • Application of CXCR2 gene in heart-related diseases
  • Application of CXCR2 gene in heart-related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] 1. Establishment of angiotensin II (Ang II)-induced hypertension model in mice

[0070] Take 6-8 week-old SPF grade male C57BL / 6 mice, after anesthesia, 75% alcohol disinfects the operation area, subcutaneously implants a micro-sustained release pump perfused with normal saline or 2000ng / kg / min Ang II in the back for 3 weeks. During this process, blood pressure was continuously monitored to confirm the successful establishment of the mouse hypertension model.

[0071] 2. Experimental grouping

[0072] They were randomly divided into 4 groups (8 rats in each group): control group, CXCR2 knockout group, Ang II group, and CXCR2 knockout+Ang II group. The Ang II group, CXCR2 knockout+Ang II group were given Ang II perfusion, and the control group and CXCR2 knockout group were given the same amount of normal saline.

[0073] 3. Establish a detection platform for Ang II-induced mouse hypertension model

[0074] General observation: development, action, fur, diet, weight, e...

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Abstract

The invention discloses application of a CXCR2 gene in preparation of a diagnosis kit or a treatment drug composition for arrhythmia-related diseases. The inventor discovers that after the CXCR2 geneis knocked out, the atrial fibrosis is improved; further, after the CXCR2 gene is knocked out, the mRNA level of an atrial fibrosis marker is also obviously improved; furthermore, an effect of protecting auricular fibrillation is achieved, which shows that CXCR2 can be used as a drug composition target applied to clinical treatment of the heart-related diseases.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the use of CXCR2 gene in preparing a diagnostic kit or a therapeutic drug composition for heart-related diseases. Background technique [0002] Arrhythmia is one of the most serious cardiovascular diseases. Its harm is that it can not only aggravate the original heart disease, but also cause sudden death of the patient. Atrial fibrillation (abbreviated as atrial fibrillation) is the most common persistent arrhythmia clinically, and its morbidity and mortality are increasing year by year. At present, there are about 10 million patients in my country. Atrial fibrillation can lead to cerebral apoplexy and heart failure, significantly increasing the mortality rate and disability rate, and has become one of the cardiovascular diseases that seriously threaten human health. At present, the molecular mechanism and prevention and treatment strategies of the development of atrial fibrillation hav...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883C12Q2600/158G01N33/6893G01N2800/32
Inventor 李汇华张云龙严啸邹磊鑫陈晨吴俞萱董志超
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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