Oscillatory flow active control based liquid droplet preparation method and device

An active control, oscillating flow technology, applied in fluid controllers, laboratory containers, chemical instruments and methods, etc., can solve the problems of affecting reliability, affecting experimental results, high cost, and improving work efficiency and controllability. The effect of good performance and simple structure

Active Publication Date: 2018-10-16
NANJING UNIV OF SCI & TECH
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The droplet generation methods can be mainly divided into two categories: passive and active. The passive micro-droplet preparation technology involves many variables. The volume and frequency of micro-droplet formation are not only related to the flow rate of the fluid and the size of the channel structure, but also It is related to the properties of the fluid (viscosity, interfacial tension), external environment and other parameters. Therefore, controlling the volume and frequency of droplets through passive droplet preparation requires a complex debugging process, which also leads to the difficulty of micro-droplet preparation. Much less flexibility
Although the active droplet preparation technology can solve the technical problems of poor volume and frequency controllability in the traditional passive droplet preparation technology, the active droplet preparation technology requires additional equipment to interfere with the droplet formation.
Due to the existence of external equipment, the structure of the active micro-droplet chip is often more complex, which affects the reliability, and the volume is larger, the cost is higher, and the portability is poor.
In addition, the external field force applied in the active control often acts on the reagent, which is easy to have adverse effects or damage to the reagent and affect the experimental results.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oscillatory flow active control based liquid droplet preparation method and device
  • Oscillatory flow active control based liquid droplet preparation method and device
  • Oscillatory flow active control based liquid droplet preparation method and device

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] combine figure 1 , a kind of liquid droplet preparation method based on the active control of oscillatory flow of the present invention, comprises the following process:

[0025] Preparation of spaced droplets of the first discrete phase: the continuous first discrete phase liquid flows in through the first liquid inlet pipe of the first T-shaped channel, and the continuous phase liquid vibrated by the oscillator passes through the second liquid of the first T-shaped channel. The liquid inlet pipe flows in; after being oscillated by the oscillator, the continuous phase liquid produces an oscillating flow similar to a sine wave, the first discrete phase liquid and the continuous phase liquid meet at the intersection of the first T-shaped channel, and the first discrete phase liquid is received by the The shear force of the continuous phase liquid breaks apart to form spaced droplets.

[0026] Synchronously prepare the droplets of the second discrete phase at intervals: ...

Embodiment 1

[0043] Single droplet preparation process:

[0044] Such as figure 2 As shown, the first liquid inlet pipe 4-1 is used as a discrete phase channel, and the first liquid inlet pipe 4-1 is connected to the driving pump 1, and the reagents with different viscosities (1cP-80cP) are slowly injected into the liquid through the driving pump 1 at a uniform speed. In the first liquid inlet pipe 4-1; asfigure 1 The second liquid inlet pipe 4-2 shown as a continuous phase channel is connected to the oscillator 3 through the pipeline, and the oscillator 3 is connected to the pressure pump 2 through the pipeline, and the pressure pump 2 drives the continuous phase liquid to flow through the oscillator 3 and generates Spontaneous oscillation makes the continuous phase liquid produce a sinusoidal oscillating flow; the stable discrete phase liquid meets the oscillating continuous phase liquid at the T-shaped channel 4, and the discrete phase liquid is broken by the shear force from the conti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an oscillatory flow active control based liquid droplet preparation method. The method comprises the steps of firstly, preparing spacing first dispersed-phase liquid droplets, then, synchronously preparing spacing second dispersed-phase liquid droplets, and finally, subjecting the first dispersed-phase liquid droplets and the second dispersed-phase liquid droplets to arranged outputting through output pipes of different lengths. The invention further discloses an oscillatory flow active control based liquid droplet preparation device. The device comprises M T-shaped passages and a negative flow resistance oscillator, wherein the negative flow resistance oscillator is used for oscillating continuous-phase liquid into sine wave similar flow, a first liquid inlet pipe of each T-shaped passage serves as an inflow passage of first dispersed-phase liquid, and a second liquid inlet pipe of the corresponding T-shaped passage serves as an inflow passage of continuous-phase liquid; and liquid outlet pipes of the M T-shaped passages are jointly connected with an output pipeline. According to the method and the device, the reliability of preparation of high-viscosity liquid droplets is improved, operating steps of generating frequency and volume during liquid droplet preparation are simplified, and meanwhile, multiple liquid droplets of different properties can be synchronously generated.

Description

technical field [0001] The invention belongs to the field of microfluidic devices, in particular to a droplet preparation method and device based on active control of oscillating flow. Background technique [0002] The droplet generation methods can be mainly divided into two categories: passive and active. The passive micro-droplet preparation technology involves many variables. The volume and frequency of micro-droplet formation are not only related to the flow rate of the fluid and the size of the channel structure, but also It is related to the properties of the fluid (viscosity, interfacial tension), external environment and other parameters. Therefore, controlling the volume and frequency of droplets through passive droplet preparation requires a complex debugging process, which also leads to the difficulty of micro-droplet preparation. Flexibility is greatly reduced. Although the active droplet preparation technology can solve the technical problems of poor volume an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/502784B01L2400/0433
Inventor 夏焕明张言引
Owner NANJING UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap