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Three-dimensional roll-like structure with self-regulating structure function, preparation method and application thereof

A technology for adjusting structure and three-dimensional tubular shape, which is applied in chemical instruments and methods, pharmaceutical equipment, and other medical equipment, etc. It can solve problems such as organ transplant failure, patient death, and outstanding antibacterial problems, and achieve the effect of simple preparation

Active Publication Date: 2022-07-15
柔脉医疗(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the failure of tissue or organ transplantation caused by acute or chronic bacterial infection, or even the death of the patient directly, is very serious in clinical practice. protrude

Method used

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  • Three-dimensional roll-like structure with self-regulating structure function, preparation method and application thereof
  • Three-dimensional roll-like structure with self-regulating structure function, preparation method and application thereof
  • Three-dimensional roll-like structure with self-regulating structure function, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] This example is used to illustrate the preparation method of the electrospinning film. For the specific scheme and results, please refer to image 3 a-c and Figure 4 a-e.

[0081] First, two degradable polymer materials with different degradation rates, PLGA and PCL, were selected as the base materials of the scaffold. As a solvent, stir and mix well for electrospinning film preparation.

[0082] Using electrospinning technology, applying a high-voltage power supply of 15kV, and selecting hexafluoroisopropanol as a solvent, two polymer solutions were prepared. The concentration of PCL solution was 10wt%, the concentration of PLGA solution was 20wt%, and the receiving distance was 15cm. The final PLGA solution The diameter is about 0.7 μm, the diameter of PCL is about 0.6 μm, and the porosity is 70%. Finally, an electrospinning film with a thickness of about 80 μm is prepared. The film has two components, one is the PCL layer with a slower degradation rate, and the ot...

Embodiment 2

[0084] This example is used to illustrate the surface modification of electrospinning films and the two-dimensional patterning of cells. For specific schemes and results, see image 3 d-f, Figure 4 f and Figure 5 a.

[0085]First, design and process a PMMA template with a three-channel (or multi-channel) structure, pour it with a PDMS solution (matrix: curing agent mass ratio of 10:1), and place it in an oven at 80 °C for heating and curing for 1 h. The cured PDMS is removed from the template. Remove the top and bottom, trim the edges, use a puncher to punch three channels (or multi-channels) (with a diameter of 8 mm), prepare microfluidic seeding chips in turn, and use the prepared three-channel cell seeding microfluidic chips for For the regionalized planting of cells, after attaching the PDMS chip to the surface of the electrospinning film, Fibronectin (50 μg / ml) was first added to modify the spinning surface to facilitate cell adhesion; then three cells were seeded. I...

Embodiment 3

[0087] This example is used to illustrate the three-dimensional transformation of the two-dimensional patterned film. For the specific scheme and results, please refer to image 3 i-h, Figure 4 g-i and Figure 5 b-c.

[0088] Pre-engineered tension-induced self-curling films ( image 3 c), it has a double-layer structure, the bottom layer is an electrospun drug-loaded film, and the upper layer is a pre-stretched PDMS strip with a strain of 70% and a thickness of about 80 μm. The spun films are glued together to form a complete layer. Since PDMS has a certain internal stress after pre-stretching, when the cells are attached, the film and PDMS strip are cut from the right side with a scalpel, and the film will be automatically curled to form a multi-layer roll structure with a specific inner diameter. . The structure has 6 layers, from inside to outside: endothelial layer, PCL layer, smooth muscle cell layer, PLGA layer, fibroblast / neural cell layer, PLGA layer.

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Abstract

The invention provides a three-dimensional roll-like structure with the function of self-adjusting structure, as well as a preparation method and application of the three-dimensional roll-like structure. The three-dimensional multi-layer rolled structure of the present invention has the function of autonomously adjusting its own structure according to the external environment, can be used as a tissue engineering blood vessel similar to a real blood vessel structure, and is applied to the fields of medical materials, tissue engineering and the like.

Description

technical field [0001] The invention belongs to the fields of medical materials and tissue engineering. In particular, the present invention relates to a three-dimensional roll-like structure with the function of self-adjusting structure, and a preparation method and application thereof. Background technique [0002] According to statistics from the World Health Organization, heart disease, especially coronary-related disease, has always been the number one fatal disease threatening human life. Among them, coronary atherosclerotic heart disease (CHD) is the disease with the highest fatality rate among acquired diseases, mainly due to the accumulation of steroids and other substances on the inner wall of blood vessels to form plaques of varying degrees, which will greatly reduce the need for blood flow. The cross-section of the vascular organ cavity, resulting in insufficient blood supply to downstream tissues and body damage. Coronary heart disease generally causes symptom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/38A61L27/18A61L27/24A61L27/50A61L27/58B32B1/08B32B27/36B32B27/28B32B3/08
CPCA61L27/18A61L27/24A61L27/3891A61L27/50A61L27/507A61L27/58B32B1/08B32B3/08B32B27/28B32B27/283B32B27/36B32B2535/00
Inventor 蒋兴宇成诗宇
Owner 柔脉医疗(深圳)有限公司
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