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Multi-gene expression characteristic spectrum-based individualized prognosis assessment method for clear cell carcinoma of kidney

A technology of renal clear cell carcinoma and gene expression profiling, applied in the field of biotechnology and medicine, to achieve the effect of precise survival status

Active Publication Date: 2018-10-12
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Problems solved by technology

However, most reports only use single or several genes, can only classify a group, and can only qualitatively divide the individual survival period (such as two indicators of good prognosis and poor prognosis)

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  • Multi-gene expression characteristic spectrum-based individualized prognosis assessment method for clear cell carcinoma of kidney
  • Multi-gene expression characteristic spectrum-based individualized prognosis assessment method for clear cell carcinoma of kidney
  • Multi-gene expression characteristic spectrum-based individualized prognosis assessment method for clear cell carcinoma of kidney

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Embodiment Construction

[0066] The implementation of the present invention will be described in detail below with examples, so as to fully understand and implement the implementation process of how the present invention uses technical means to solve technical problems and achieve technical effects.

[0067] The invention discloses a method for evaluating the individualized prognosis of clear cell renal cell carcinoma based on a polygene expression profile, comprising the following steps:

[0068] Step 1. Obtain the list of prognostic risk genes and gene weights for clear cell renal cell carcinoma, specifically:

[0069] Step 1.1, download the tumor tissue and paracancerous tissue transcriptome data and clinical data of clear cell renal cell carcinoma patients from the Genomic Data Commons Data Portal database, and obtain the gene expression profile FPKM (Fragments Per Kilobase of transcript per Million Fragments mapped) value, logarithmic transformation (log2).

[0070] Step 1.2, set the total numbe...

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Abstract

The invention discloses a multi-gene expression characteristic spectrum-based individualized prognosis assessment method for clear cell carcinoma of kidney. The method comprises the following steps of: obtaining a clear cell carcinoma of kidney prognosis risk gene list and a gene weight; constructing a prognosis assessment model by utilizing tumor tissue transcriptomes and survival data of a patient with clear cell carcinoma of kidney; calculating a risk score of the patient according to gene expression profile of tumor tissues of the patient with the clear cell carcinoma of kidney; and calculating an annual survival probability of the patient according to the risk score of the patient. According to the method, the annual survival probabilities of patients with the clear cell carcinoma ofkidney are highly consistent with the practical annual survival rates (linear dependence R2=0.999, P=8.21E-74), so that the method has high prediction correctness and is highly identical with practical survival states; and meanwhile, for each tumor patient, the method is capable of giving s peculiar survival probability curve of the patient.

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to a personalized prognosis evaluation method for renal clear cell carcinoma based on multi-gene expression profile. Background technique [0002] Clear cell renal cell carcinoma is a type of renal cell carcinoma, accounting for 60% to 70% of renal cancers. Clear cell renal cell carcinoma of unknown etiology mainly affects men aged 60-70 years. Patients with clear cell renal cell carcinoma usually have a good prognosis. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from kidney cancer worldwide reached 1.3 million, of which 166,000 were in China. In 2016, the global death toll of kidney cancer patients was 132,000, accounting for 0.24% of the total death toll. In 2016, the number of patients who died in China was 16,000, accounting for 0.17% of the total number of deaths. The statistical results show that from 1990 to...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/20G06F19/24
CPCG16B25/00G16B40/00
Inventor 李文兴李功华黄京飞赵旭东代绍兴
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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