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Ketotifen fumarate tablet and preparation method thereof

A technology of ketotifen fumarate and ketone fumarate, which is applied in the field of medicine, can solve the problems of Gram-positive bacteria, the influence of heat source, and its use is not recommended, so as to eliminate the possibility of heat source and reduce the risk of heat source. Effect

Inactive Publication Date: 2018-09-25
JIANGSU PENGYAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, ketotifenol fumarate is used in nasal sprays or tablets. Since some of the objects are children, the use of sprays may cause discomfort if improperly handled, so it is not recommended to use them; and if tablets are used, there is a heat source effect, which may cause skin irritation. Invasion of Lambert-positive bacteria

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] The ketotifen fumarate tablet consists of 50 parts by mass of ketotifen fumarate, 5 parts of hydroxypropyl cellulose, 1 part of magnesium stearate and 1 part of starch.

Embodiment 2

[0014] The ketotifen fumarate tablet consists of 80 parts by mass of ketotifen fumarate, 10 parts of hydroxypropyl cellulose, 5 parts of magnesium stearate and 2 parts of starch.

Embodiment 3

[0016] The ketotifen fumarate tablet consists of 60 parts by mass of ketotifen fumarate, 7 parts of hydroxypropyl cellulose, 2 parts of magnesium stearate and 1 part of starch.

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PUM

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Abstract

The invention discloses a ketotifen fumarate tablet, which is prepared from the following components in parts by mass: 50 to 80 parts of ketotifen fumarate, 5 to 10 parts of hydroxy propyl cellulose,1 to 5 parts of magnesium stearate and 1 to 2 parts of starch. Meanwhile, the invention further discloses a preparation method of the ketotifen fumarate tablet. By pretreating the ketotifen fumarate in a low temperature environment, the heat source risk in the ketotifen fumarate raw material is lowered, in a subsequent preparation process, low temperature preparation is continued, and the possibility of existence of the heat source is further avoided.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a ketotifen fumarate tablet and a preparation method thereof. Background technique [0002] Ketotifen fumarate is a second-generation histamine H1 receptor antagonist with strong histamine H1 receptor antagonistic effect. It was launched in 1979 and is used in Europe, Asia, Australia and many other regions. Chinese Pharmacopoeia 2000 edition Pack its tablets. Ketotifen fumarate is clinically mainly used for the prevention and quality of allergic asthma and allergic rhinitis asthma syndrome, and is considered to be a drug with steroid-like effects but without steroid side effects. Ketotifen fumarate is particularly effective in the treatment of children's asthma, with a curative effect of more than 80%. At present, ketotifenol fumarate is used in nasal sprays or tablets. Since some of the objects are children, the use of sprays may cause discomfort if improperly handled, so i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K31/4535A61P11/06A61P11/02A61P37/08
CPCA61K9/2054A61K9/2059A61K9/2095A61K31/4535A61P11/02A61P11/06A61P37/08
Inventor 周健蒋锋王顺
Owner JIANGSU PENGYAO PHARMA
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