Cancer neoepitopes

A new epitope, cancer technology, applied in the direction of cancer antigen components, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, antibody medical components, etc.

Inactive Publication Date: 2018-09-07
NANTOMICS LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In practice, routine production of monoclonal antibodies against a single antigen typically takes months

Method used

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  • Cancer neoepitopes
  • Cancer neoepitopes
  • Cancer neoepitopes

Examples

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Embodiment Construction

[0021] The inventors have discovered that various diagnostic and therapeutic compositions and medicaments can be prepared according to a conceptually simple and efficient method that combines in silico and in vitro techniques.

[0022]It should now be recognized that, using the inventors' systems and methods, fully synthetic antibodies can be generated against one or more patient-specific neo-epitopes, particularly antibodies against antigens that have not elicited a protective immune response and / or against expressed Antibodies to antigens that suppress the immune response. It should be noted that, more advantageously, such synthetic antibodies can be prepared by in silico analysis of patient omics data, resulting in a relatively large number of potentially useful neo-epitopes, which can then be further filtered to improve therapeutic efficacy. efficacy. Viewed from another perspective, the synthetic monoclonal antibodies of the present invention are produced without the act...

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Abstract

Contemplated compositions and methods are directed to cancer neoepitopes and uses of such neoepitopes, especially to generate synthetic antibodies against neoepitopes that may then be employed in themanufacture of a therapeutic agent. Preferred therapeutic agents will comprise a synthetic antibody against a neoepitope, and most preferably in combination with a cellular or non-cellular component for use as a diagnostic or therapeutic agent.

Description

[0001] This application claims co-pending U.S. Provisional Application Serial No. 62 / 178956 filed April 23, 2015 and co-pending U.S. Provisional Application Serial No. 62 / 159145 filed May 8, 2015 Priority, both applications are hereby incorporated by reference. technical field [0002] The field of the invention is cancer neoepitopes, in particular the identification of neoepitopes and their use in the generation of neoepitope-specific antibodies, and the use of neoepitopes and neoepitope-specific antibodies in prophylaxis and therapy the use of. Background technique [0003] The Background Description includes information that may be helpful in understanding the present invention. The Background Description is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, nor is any publication explicitly or implicitly referenced to be prior art. [0004] It is well known in the art that most, if not all, neoplast...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C40B30/02C07K16/00A61K35/17A61K47/50A61K49/00A61P35/00G16B5/00G16B20/20G16B20/30G16B20/50G16B30/00G16B35/20
CPCA61K35/17C07K16/30C07K16/32C07K2317/32C12Q1/6886A61K2039/55A61K2039/585C12Q2600/106C12Q2600/156C12Q2600/158G16B20/00G16B30/00G16B35/00G16C20/60C07K16/005A61P35/00A61K38/1774A61K39/0011A61K2039/505C07K2317/34G16B20/30G16B35/20G16B20/50G16B5/00G16B20/20A61K39/395A61K39/39558A61K45/05C07K14/70535C07K2317/622C07K2317/92
Inventor 安德鲁·阮卡瓦·尼亚兹帕特里克·颂-雄沙赫入兹·拉比扎德斯蒂芬·查尔斯·本茨
Owner NANTOMICS LLC
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