Application of butylphthalide in the preparation of antifungal products and its products

A technology of butylphthalide and products, which is applied in the field of medicine, can solve problems such as no literature reports, achieve strong effects, reverse drug resistance, and enhance antibacterial activity

Active Publication Date: 2020-04-24
QIANFOSHAN HOSPITAL OF SHANDONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A recent literature search found that other compounds that are also celery extracts have been proven to have anti-Candida activity, but there is no literature report on the in vitro effect of NBP on Candida, which has broad research prospects

Method used

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  • Application of butylphthalide in the preparation of antifungal products and its products
  • Application of butylphthalide in the preparation of antifungal products and its products
  • Application of butylphthalide in the preparation of antifungal products and its products

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Embodiment Construction

[0032] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0033] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations and / or combinations thereof.

[0034] As introduced in the background art, antifungal drugs commonly used in the prior art have inherent drug resistance or acquire drug resistance quickl...

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Abstract

The invention discloses application of single use of butyphthalide (NBP) and combined use of the NBP and a triazole drug and a product of the NBP. During single use of the NBP, the minimum inhibitoryconcentration for candida albicans, candida glabrata and candida krusei is 128 [mu]g / mL, and a new concept is provided for treatment of monilial infection and research and potential application of newpharmacological action of the NBP. During respective combined use of the NBP with FLC, VRC and ITC, the antibacterial activity of a triazole antifungal drug to candida can be improved; a synergisticantifungal effect can be achieved, and the drug resistance of drug-resistant candida to the triazole antifungal drug can be reversed; a research direction is provided for development of new drugs andnew use of old drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of butylphthalide in the preparation of antifungal products and the products thereof. Background technique [0002] Due to the extensive application of immunosuppressants, chemotherapy drugs, broad-spectrum antibiotics, and hormones, fungal infection has become a common complication in patients with immunodeficiency such as organ transplantation, tumors, and AIDS, and is the main cause of poor prognosis for patients. Candida is the most common opportunistic pathogen among fungi. Although the threat of Candida infection to the clinic is not as great as that caused by Aspergillus infection, such fungi are prone to enhanced drug efflux and gene target changes (such as ERG11 ) and so on, making the Candida sensitive to azole antifungal drugs to continuously develop drug resistance, which brings great challenges to clinical antifungal infection. Data show that more t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K31/4196A61K31/496A61K31/506A61P31/10
CPCA61K31/365A61K31/4196A61K31/496A61K31/506A61P31/10A61K2300/00
Inventor 孙淑娟宫颖刘伟国时银萍
Owner QIANFOSHAN HOSPITAL OF SHANDONG
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