Rat brain stereotaxic fitting device

Abstract

The invention discloses a rat brain stereotaxic fitting device. A work table is provided with a first step surface and a second step surface from top to bottom; two upright posts are arranged at the position, along the width, on the first step surface; limit holders are fixedly connected to the positions, at the same height, of the same sides of the two upright posts; each limit holder is providedwith a through hole of which the axis direction parallel to the width of the first step surface; an ear bar is inserted in each through hole in a sliding adjustable manner; the opposite ends of the two ear bars are tip ends. An adjusting mechanism can realize sliding adjustment along the length of the second step surface and is connected with a front tooth rod; the front tooth rod comprises a horizontal plate and a vertical bar; the vertical bar is arranged on the adjusting mechanism and capable of sliding for adjustment along the vertical direction, one end of horizontal plate is fixedly connected to the top end of the vertical bar, the other end of the horizontal plate is provided with a front tooth hole and extends along a gap between the two upright posts. The fitting device is used for fixing rat's head for biological study tests.

Description

technical field [0001] The invention relates to an animal experiment device, in particular to an adapter for three-dimensional fixation of a mouse brain. Background technique [0002] Studying the firing activity of neurons in the visual system of rats and mice, combined with cell and molecular biology studies, has important theoretical value for further exploring the cellular and molecular mechanisms of visual information processing and visual plasticity, but the existing stereotaxic instruments for rats and mice are limited. The head fixation methods of animals block most of the animal's field of vision, which is not suitable for the study of evoked electrical activity of cells in the visual system. [0003] At present, the stereotaxic apparatuses on the market mainly contain two categories: 1) stereotaxic apparatuses for large animals (monkeys and cats, etc.), which are mainly used for electrophysiological recordings of monkeys and cats. Because the distribution of facia...

AI Technical Summary

Problems solved by technology

However, the distribution of facial organs in rats and mice is slightly horizontal in space, and the vertical distance between the eyes and the mouth is very small. Using this brain stereotaxic instrument can not fix the rat's head firmly, and it will block the animal's field of vision

2) For small animal (rat / mouse) brain stereotaxic instrument, the head of the animal can be firmly fixed by using ear bars and incisors. A flat surface, thus blocking most of the animal's field of view, cannot normally present the animal with visual stimuli, and is therefore not suitable for visual electrophysiological recording experiments

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