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Composition for preventing or treating hair loss or promoting hair growth or hair restoration comprising diosmin as active ingredient

A technology of geranin, an effective ingredient, applied in the field of compositions for promoting hair growth or growth

Inactive Publication Date: 2018-08-31
IND ACADEMIC CORP FOUND YONSEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, reports on the anti-hair loss or hair growth-promoting activity of diosmin are unprecedented

Method used

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  • Composition for preventing or treating hair loss or promoting hair growth or hair restoration comprising diosmin as active ingredient
  • Composition for preventing or treating hair loss or promoting hair growth or hair restoration comprising diosmin as active ingredient
  • Composition for preventing or treating hair loss or promoting hair growth or hair restoration comprising diosmin as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1: Hair growth promoting effect of diosmin

[0057] 1-1. Breeding of experimental animals and application of samples

[0058] Sample preparation

[0059] Excipients (Vehichle, ethanol: water: propylene glycol = 5: 3: 2), minoxidil (MXD) as a control drug, and diosmin (DSM) as a test drug were obtained from Sigma-Aldrich (Co., Ltd.) The company buys.

[0060] Feeding of experimental animals

[0061] 24 6-week-old male C57BL / 6N mice were purchased from South Korea’s ORIENT BIO (strain), and after being adapted to the feeding room environment for 2 weeks, they were divided into negative control group (Con group), positive control group (MXD group) and incense group. A total of 3 groups of the phylloside group (DSM group) were used for the experiment. The temperature of the animal breeding room is 21±2.0° C., the relative humidity is 50±5%, and the environment is kept in a day and night cycle every 12 hours. During the experiment, the above-mentioned mice were ...

Embodiment 2

[0075] Example 2: Protein and gene expression regulation of mouse skin tissue caused by diosmin

[0076] 2-1. Changes in the expression of proteins related to hair growth promotion in skin tissue

[0077] Immunohistological Analysis Methods

[0078] Recently, intracellular signaling active factors such as Wnt / β-catenin have been found to have effects on hair growth and shedding, and these factors have attracted attention as new targets for drugs that inhibit hair loss and promote hair growth. Therefore, in order to confirm whether the Wnt / β-catenin signaling system involved in the prevention of hair loss and the promotion of hair growth (or hair growth) in skin tissue is activated by 4 weeks of sample application, etc., investigations were carried out using immunohistochemical methods .

[0079] In order to observe the expression levels of insulin-like growth factor-1 and β-catenin related to hair growth in skin tissue, the primary antibodies against insulin-like growth fact...

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating hair loss or for promoting hair growth or hair restoration; and a quasi-drug, a cosmetic composition, a functional food composition or a food composition for improving hair loss or promoting hair growth or hair restoration, comprising diosmin or a pharmaceutically acceptable salt thereof. According to the present invention, the composition of the present invention not only contains, as an active ingredient, a natural compound having no side effects even when administered for a long period of time for hairloss, which is a chronic disease, but also exhibits excellent and stable effects of hair growth and hair restoration, so that the present invention can be usefully employed as an effective hair loss preventing or treating agent, or as a quasi-drug / cosmetic / functional food / food composition for promoting hair growth or hair restoration.

Description

[0001] This application claims the priority of Korean Patent Application No. 10-2015-0188799 filed on December 29, 2015, and the entirety of the above specification is cited in this application. technical field [0002] The present invention relates to a composition for preventing or treating alopecia or promoting hair growth or growth, comprising diosmin or a pharmaceutically acceptable salt thereof as an active ingredient. Background technique [0003] According to the National Health Insurance Corporation’s Health Insurance Policy Research Institute’s analysis of health insurance medical expenses payment data from 2001 to 2008, the actual number of patients diagnosed with “hair loss disease” increased from 103,000 in 2001 to 2005. 142,000, and reached 165,000 in 2008, an increase of 60% over the past seven years. According to age statistics, the actual number of patients in the 20-40 age group was 114,000, accounting for 69.5% of the patients, and there were more than 22,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61K8/60A61K8/49A23L33/10A61Q7/00A61Q19/00
CPCA23L33/10A61K8/49A61K8/60A61K31/352A61K31/7048A61Q7/00A61Q19/00
Inventor 朴太瑄
Owner IND ACADEMIC CORP FOUND YONSEI UNIV
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