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Applications of cefalotin sodium in anti-leukemia drugs

A technology of cefalotin sodium and leukemia, which is applied in the field of medicine and can solve the problems that the application of cefalotin sodium has not been reported.

Inactive Publication Date: 2018-07-31
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far, the application of cefalotin sodium in anti-mixed lineage leukemia and other leukemias has not been reported.

Method used

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  • Applications of cefalotin sodium in anti-leukemia drugs
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  • Applications of cefalotin sodium in anti-leukemia drugs

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Embodiment Construction

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. All other embodiments obtained by persons of ordinary skill in the art based on the embodiments of the present invention belong to the protection scope of the present invention.

[0018] Cefalotin sodium is:

[0019]

[0020] The CAS number of the cefalotin sodium involved in the present invention is 58-71-9, which is provided by the High-throughput Drug Screening Center of the Tianjin International Joint Research Institute of Biomedicine.

[0021] In the present invention, method steps such as expression and purification of histone lysine methyltransferase DOT1L in proteins related to mixed lineage leukemia and compound screening methods reference methods (Basavapa...

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Abstract

The invention provides applications of cefalotin sodium in preparation of drugs used for preventing or treating leukemia, and especially applications of cefalotin sodium in preparation of drugs used for preventing or treating mixed-lineage leukemia (MLL). According to an application method, histone lysine methyltransferases DOT1L participating in gene rearrangement of mixed-lineage leukemia is taken as a target protein, SPR technology is adopted, and cefalotin sodium with inhibition effect on the target protein is selected as an inhibitor; cefalotin sodium is combined with the target protein so as to inhibit the activity of the target protein, prevent participation of DOT1L in MLL gene rearrangement process, and prevent and treat leukemia. The invention also provides a drug used for preventing or treating leukemia.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of cefalotin sodium in anti-leukemia medicines Background technique [0002] Mixed lineage leukemia (Mixed Lineage Leukemia, MLL) is a hematological malignancy. It is named after the formation of MLL fusion protein after MLL gene rearrangement. The MLL gene is located on chromosome 11, zone 2, band 3 (11q23). Associated with hematologic malignancies. Acute leukemia positive for MLL gene rearrangement can occur from birth to adulthood, manifested as acute myeloid leukemia (AML) or acute lymphoblastic leukemia (acutelymphoblastic leukemia, ALL). Although there will be some errors, in a research survey of related literature, it was found that 11q23 chromosomal translocation or MLL gene rearrangement occurred in 22% of ALL patients after integrating the data of 7969 AML patients and 1252 ALL patients and 5.2% of AML patients. About 14% of children with acute myeloid leukem...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61P35/02
CPCA61K31/546A61P35/02
Inventor 杨诚刘祥徐晓林赵换李召
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
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