Application of amlodipine and cephalosporins in the preparation of anti-resistant combination antibiotics

A technology of amlodipine and cephalosporins, which is applied in the field of medical biology and can solve the problems of long development cycle and high cost of research and development of new antibiotics

Active Publication Date: 2020-01-10
易子越
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AI Technical Summary

Problems solved by technology

The treatment of positive drug-resistant bacteria can rely on new β-lactam antibiotics; however, in the short term, drug-resistant bacteria will adapt to new antibiotics again, and the development cost of new antibiotics is high and the development cycle is long

Method used

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  • Application of amlodipine and cephalosporins in the preparation of anti-resistant combination antibiotics
  • Application of amlodipine and cephalosporins in the preparation of anti-resistant combination antibiotics
  • Application of amlodipine and cephalosporins in the preparation of anti-resistant combination antibiotics

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0092] Experimental Principles and Methods

[0093] 1. Bacterial culture

[0094] 2. Test the inhibition sensitivity of bacteria to different drugs, combinations and concentrations

[0095] 3. Compare the bacterial inhibition sensitivity of various single drugs, and the bacterial inhibition sensitivity of besylate and amlodipine in combination with various corresponding drugs

[0096] 4. Using 96-well bacterial culture plate, absorbance test, (partial) bacterial activity staining

[0097] Experimental Drug Materials

[0098] MRSA

[0099] 1. Drug-resistant S. aureus strains

[0100] The strains are derived from the specimens submitted for clinical examination, and are obtained through bacterial identification and drug sensitivity screening after separation. The detection result of the Mérieux identification instrument VITEK2 is 99%, the biological code: 010402062763231 (the identification result of the instrument is attached).

[0101] 2. Benzenesulfonic acid. Amlodipine...

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Abstract

The invention belongs to the technical field of medical biology, and particularly relates to application of amlodipine and cephalosporin medicines to preparation of medicine-resistant combined antibiotics. After computational biology indicates that amlodipine has an inhibitory effect on beta-lactam hydrolase, medicine testing is performed by using MRSA and acinetobacter bauamnnii as models, and through combination with cephalosporin antibiotics, a relatively good bacteriostatic effect on the MRSA is achieved; novel application is provided for the amlodipine, and a novel medicinal composition is provided for positive medicine-resistant bacteria; other more effective combinations containing the amlodipine can be further developed; the conventional cephalosporin and amlodipine combinations are mature in technology, few in side effects and low in cost; and the amlodipine and cephalosporin medicines can be applied to preparation of the medicine-resistant combined antibiotics, preparation ofbeta-lactam medicine-resistant bacterium inhibiting combined antibiotics and preparation of medicines for treating respiratory infection, wound infection and infection caused by all positive bacteria.

Description

[0001] a technical field [0002] The invention belongs to the technical field of medicine and biology, and in particular relates to the application of amlodipine and cephalosporins in the preparation of anti-drug-resistant combination antibiotics. [0003] Two background technology [0004] With the abuse of antibiotics, multi-drug resistant bacteria have emerged all over the world, including MRSA and Acinetobacter baumannii. Such bacteria are mostly found in places where antibiotics are abused, such as hospitals. Because multi-drug resistant bacteria are resistant to drugs, the lethal rate is high; on the other hand, bacteria adapt to new antibiotics faster than antibiotics are developed. The treatment of positive drug-resistant bacteria can rely on new β-lactam antibiotics; however, in the short term, drug-resistant bacteria will adapt to new antibiotics again, and the development cost of new antibiotics is high and the development cycle is long. [0005] In addition to ne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61K45/06A61K31/546A61P31/04A61P11/00A61P17/02
CPCA61K31/4422A61K31/546A61K45/06A61K2300/00
Inventor 易子越
Owner 易子越
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