Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury

A technology of dihydroxyphenyl and activator, applied in the field of medicine

Active Publication Date: 2018-06-08
CHINA PHARM UNIV
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Protocatechualdehyde, danshensu, salvianolic acid B and salvianolic acid A belong to salvianolic acid compounds, and there is no report on salvianolic acid compounds used as ALDH2 activators

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury
  • Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury
  • Purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Experimental materials

[0051] 1.1 Instruments and equipment

[0052] Ultra-clean bench (Thermo Scientific 1300A2, USA); multifunctional microplate reader FLUOstar Omega (BMG LABTECH, Germany); electronic scale (Tianjin Tianma Hengji Instrument Co., Ltd.); Sartorius analytical balance (Beijing Doris Balance Co., Ltd.); Eppendorf Desktop multifunctional high-speed centrifuge (type 5430, Germany).

[0053] 1.2 Reagents

[0054] Standard products: protocatechualdehyde, danshensu, salvianolic acid B, and salvianolic acid A were purchased from Chengdu Master Biotechnology Co., Ltd.

[0055] Reagents: DMEM high-glucose medium, fetal bovine serum, 100× penicillin and streptomycin (Thermo Fisher, USA); PBS (Beijing Boaosen Biotechnology Co., Ltd.); CCK8 (Shanghai Dongren Chemical Technology Co., Ltd.); DMSO (sigma, the United States); ALDA-1 (MedChem Express); mitochondrial acetaldehyde dehydrogenase 2 activity detection kit (abcam, UK); rat 4-hydroxynonenoic acid ELISA ...

Embodiment 2

[0168] 1. Tablet

[0169] Protocatechualdehyde, danshensu, salvianolic acid B or salvianolic acid A 70g, starch 180g, magnesium stearate 3g.

[0170] Preparation process: Danshensu, salvianolic acid B or salvianolic acid A, starch and magnesium stearate are mixed uniformly, granulated, dried, and compressed into tablets.

[0171] 2. Capsules

[0172] Meliasenin B, C or D 70g, starch 180g, magnesium stearate 3g.

[0173] Preparation process: Danshensu, salvianolic acid B or salvianolic acid A, starch and magnesium stearate are mixed and granulated, dried and packed into capsules.

[0174] In summary, the present invention provides 3,4-dihydroxyphenyl substituted phenolic compounds including but not limited to protocatechualdehyde, danshensu, salvianolic acid B, and salvianolic acid A for the preparation of ALDH2 activators Uses, and further provide the use of the 3,4-dihydroxyphenyl substituted phenolic compound for the preparation of drugs for the prevention and treatment o...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a purpose of 3,4-dihydroxy phenyl substituted phenol for preparing an ALDH2 activating agent and medicine for preventing and treating cardio-cerebral ischemia injury. The invention provides a purpose of a 3,4-dihydroxy phenyl substituted phenol compound including but not limited to protocatechuic acid, tanshinol, danshinolic acid B and danshinolic acid A for preparing the ALDH2 activating agent, and further provides a purpose of the 3,4-dihydroxy phenyl substituted phenol compound for preparing medicine for preventing and treating cardio-cerebral ischemia injury; a medicine composition for preventing and controlling myocardial infarction or cerebral apoplexy by 3,4-dihydroxy phenyl substituted phenol or pharmaceutical salts of the 3,4-dihydroxy phenyl substituted phenol. The 3,4-dihydroxy phenyl substituted phenol or pharmaceutical salts of the 3,4-dihydroxy phenyl substituted phenol can be used for preparing medicine for preventing and controlling diseases relevant to ALDH2.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of a compound, in particular to the application of 3,4-dihydroxyphenyl substituted phenol in the preparation of an ALDH2 activator and a drug for preventing and treating heart and brain ischemia injury. Background technique [0002] According to statistics, 3 million people die from ischemic cardiovascular and cerebrovascular diseases in my country every year, accounting for about 40% of all deaths. Ischemic cardiovascular and cerebrovascular diseases have become the diseases with the highest morbidity, disability and mortality in my country. . At present, many pathways related to cardio-cerebral ischemia injury have been discovered, and intervention of these pathways can reduce the damage of cardio-cerebral ischemia to cardiomyocytes and nerve cells (Reference: The Pathogenesis of Brain Injury Induced by Ischemia, Chinese Practical Medicine, Volume 3, Issue 25, September 2...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/343A61K31/216A61K31/192A61K31/11A61P9/10
CPCA61K31/11A61K31/192A61K31/216A61K31/343
Inventor 李萍杨华祁励丰荣蒋黎锋曾昊余莹华
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com