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Ginkgolide derivative and application thereof

A technology of ginkgolide and derivatives, applied to pharmaceutically acceptable salts and applications thereof, in the field of ginkgolide derivatives, can solve problems such as insufficient drug efficacy and oral efficacy

Inactive Publication Date: 2018-05-29
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing ginkgolide compounds have insufficient drug efficacy and oral effectiveness, so it is necessary to modify their structure in order to find a better compound

Method used

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  • Ginkgolide derivative and application thereof
  • Ginkgolide derivative and application thereof
  • Ginkgolide derivative and application thereof

Examples

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Embodiment Construction

[0016] As mentioned above, the present invention aims to provide a ginkgolide derivative, a pharmaceutically acceptable salt and its application. A specific description will be given below in conjunction with the contents of the experimental example.

[0017] In particular, it should be pointed out that similar replacements and modifications made to the present invention will be obvious to those skilled in the art, and they are all considered to be included in the present invention. Relevant persons can realize and apply the technology of the present invention by making changes or appropriate changes and combinations to the methods and applications described herein without departing from the content, spirit and scope of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, but not all of them.

[0018] If the present invention does not indicate the specific conditions, it is carried out according to the convent...

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PUM

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Abstract

The invention discloses a ginkgolide derivative and an application thereof. Ginkgolide is modified to obtain a series of ginkgolide B or K derivatives. The biological structural formula of the ginkgolide derivative is as shown in a formula I, II, III or IV. Experiments show that after a GB or GK structure is improved, activity of a compound is improved, and activity is obviously improved after alkyl is connected with morpholine or piperazine. The derivative has a wide application prospect in prevention or treatment of cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to ginkgolide derivatives, pharmaceutically acceptable salts and applications thereof. Background technique [0002] Cerebral ischemia / reperfusion injury is a serious hazard to human life and health. According to relevant research reports, it accounts for about 70%-85% of cerebrovascular diseases, and its pathophysiological process is also very complicated. It can not only cause cell necrosis in the early stage, but also Can induce apoptosis at a late stage. The abnormality of platelet (blood platelet, PLT) function plays an important role in cerebral ischemia-reperfusion injury. In the ischemic brain tissue, due to the stimulation of various incentives, the adhesion of PTL is enhanced and aggregated, which reduces the blood flow of the brain tissue. , hinder the recovery of cell function; in the process of reperfusion, the abnormal increase of oxygen free rad...

Claims

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Application Information

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IPC IPC(8): C07D493/22A61K31/5377A61K31/496A61P9/10
CPCC07D493/22
Inventor 萧伟曹泽彧胡晗绯袁扬李卓琼许治良王振中
Owner JIANGSU KANION PHARMA CO LTD
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