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Application of natural deep-eutectic solvent used as preservative

A low eutectic solvent and preservative technology, which can be applied to medical preparations containing active ingredients, cosmetic preparations, preparations for skin care, etc.

Active Publication Date: 2018-05-29
SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Generally, natural products such as flavonoids, terpenes, and phenolic acids have antiseptic properties, but their antibacterial properties are weak

Method used

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  • Application of natural deep-eutectic solvent used as preservative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A kind of natural deep eutectic solvent, is made by following method: Choline chloride and hydrogen bond donor compound (composed of glycerol and urea) are mixed according to molar ratio 1:2, and total mass is 50g, adds to round bottom flask successively Put it in a water bath at 60°C and keep stirring for 0.5h to form a transparent liquid.

Embodiment 2

[0026] A kind of natural deep eutectic solvent, is made by following method: betaine and hydrogen bond donor compound (made up of citric acid and glycerol) are mixed according to molar ratio 1:1, and total mass is 50g, adds in the round bottom flask successively , placed in a water bath at 80°C and stirred continuously for 3h, a transparent liquid was formed.

Embodiment 3

[0028] A natural deep eutectic solvent, prepared by the following method: L-proline and hydrogen bond donor compound (composed of malic acid and glycerol) are mixed according to the molar ratio of 1:1, the total mass is 45g, and added to the circle successively In the bottom flask, put it in a water bath at 80°C and keep stirring for 1 hour, and then a transparent liquid will form.

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Abstract

The invention discloses application of a natural deep-eutectic solvent used as a preservative. The natural deep-eutectic solvent is synthesized by a method with the following steps of mixing a hydrogen bond donor compound and a hydrogen bond receptor compound according to a molar ratio of 1.0:(0.5 to 2.0), and heating to react until a transparent liquid solvent is formed, wherein the hydrogen bonddonor compound is selected from one or more than one of glycerin, citric acid, urea, malic acid or xylitol, and the hydrogen bond receptor compound is selected from one or more than one of choline chloride, glycine betaine or L-proline. The invention also discloses a compounded preservative, and the compounded preservative is prepared from 10 to 50% of natural deep-eutectic solvent and 2.5 to 5.3% of folium mori extract. The natural deep-eutectic solvent is reported for the first time, and has the advantages that the bacteria-inhibiting and anti-corrosive functions are realized; the natural deep-eutectic solvent is compounded with the folium mori extract to form the novel preservative, and the bacteria-inhibiting function of the preservative is improved.

Description

technical field [0001] The present invention relates to the use of natural deep eutectic solvents as preservatives. Background technique [0002] Preservatives refer to a class of substances that can inhibit the growth of microorganisms, and are generally divided into chemical preservatives, natural preservatives and compound preservatives. Adding preservatives can effectively control products from microbial contamination. In practical applications, since preservatives are difficult to inhibit broad-spectrum microorganisms, the products often have problems such as turbidity, precipitation and color changes due to bacterial contamination, which seriously affect product quality. [0003] At present, chemical preservatives are widely used, such as chemical preservatives such as benzoic acid and its salts, sorbic acid and its salts, and parabens. It has side effects and even has the potential risk of inducing cancer. At the same time, chemical preservatives are highly irritat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/49A61K8/44A61K8/42A61K8/41A61K8/365A61K8/34A61Q19/00
CPCA61K8/345A61K8/365A61K8/416A61K8/42A61K8/44A61K8/4913A61K8/97A61K2800/10A61K2800/524A61K2800/5922A61Q19/00
Inventor 邝哲师周鹏飞罗国庆黄静唐翠明王振江戴凡炜
Owner SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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