A kind of preparation method and application of antibacterial coating on dental implant surface

A dental implant and surface antibacterial technology, applied in coatings, prostheses, medical science, etc., can solve the problems of easy falling off, inability to sterilize for a long time, high cost of antibacterial peptides, etc., and achieve high safety effects

Active Publication Date: 2021-02-05
BEIJING UNIV OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN 105536063 A adopts the method of dispersing antibiotics into polylactic acid bases to prepare antibacterial coatings. This method utilizes the slow-release sterilization of antibiotics, which leads to drug resistance and cannot be sterilized for a long time
Patent CN 106725937A combines chitosan and antimicrobial peptide modified by positive and negative electrostatic attraction of anions and cations to the surface of the implant. This method has the problem of weak combination and easy falling off, and the antibacterial effect of chitosan is not good, and antimicrobial peptide higher cost
The patent CN105343929 A modified the polymer quaternary ammonium salt on the surface of the implant. Although it has a long-term antibacterial effect, the antibacterial component is single and cannot be used for the preparation of surface coatings with complex structures.

Method used

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  • A kind of preparation method and application of antibacterial coating on dental implant surface
  • A kind of preparation method and application of antibacterial coating on dental implant surface

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare a 1mg / mL dopamine aqueous solution, put the treated metal titanium disk into the above solution, react for 2 hours, and the reaction temperature is 30°C, take out the titanium piece, clean it and dry it. Add BiBB to DMSO at a concentration of 4.3×10 -4 mol / mL, add the above titanium sheet. Dissolve glycidyl methacrylate in ethanol at a concentration of 4.3×10 -2 mol / mL, then add the above-mentioned titanium sheet and add CuBr 8mg / mL, PMDETA 20uL / mL, react for 1h, take out the titanium sheet, wash and dry. Dissolve 2 mL of ethylenediamine in 4 mL of organic solvent DMSO, add the titanium sheet obtained above and react for 2 h, prepare a 2.5% glutaraldehyde solution, and put the above titanium sheet. Prepare 5 mg / mL of quaternized PEI 600 solution, and put in the above-mentioned titanium sheet. Escherichia coli was used for antibacterial experiments, and the bacterial solution was 10 6 CFU, co-cultivate the titanium sheet and the bacterial solution at 37°C for...

Embodiment 2

[0022] Prepare 2mg / mL dopamine aqueous solution, put the metallic titanium disk into the above solution, react for 3h, the reaction temperature is 30°C, take out the titanium disk, clean it and dry it. Add BiBB to DMSO at a concentration of 4.3×10 -4 mol / mL, add the above titanium sheet. Dissolve glycidyl methacrylate in ethanol 4.3×10 -2 mol / mL, then add the above-mentioned titanium sheet, add CuBr 8mg / mL, PMDETA 20uL / mL, react for 2h, take out the titanium sheet, wash and dry. Dissolve 2 mL of ethylenediamine in 4 mL of organic solvent DMSO, add the titanium sheet obtained above and react for 2 h, prepare a 3% glutaraldehyde solution, and put the above titanium sheet. Prepare 6 mg / mL of quaternized PEI 600 solution, and put in the above-mentioned titanium sheet. Escherichia coli was used for antibacterial experiments, and the bacterial solution was 10 6 CFU, co-cultivate the titanium sheet and the bacterial solution at 37°C for 6h. The experimental group is the titanium...

Embodiment 3

[0024] Prepare 3mg / mL dopamine aqueous solution, put metal titanium disk into the above solution, react for 4h, reaction temperature is 30°C, take out the titanium piece, wash and dry. Add BiBB to DMSO at a concentration of 4.3×10 -4 mol / mL, add the above titanium sheet. Dissolve glycidyl methacrylate in ethanol 4.3×10 -2 After mol / mL, add the above-mentioned titanium sheet, add CuBr 8mg / mL, PMDETA 20uL / mL, react for 3h, take out the titanium sheet, wash and dry. Dissolve 2mL of ethylenediamine in 4mL of organic solvent DMSO, add the titanium sheet obtained above and react for 2h, prepare a 3.5% glutaraldehyde solution, and put the above titanium sheet. Prepare 7 mg / mL of quaternized PEI 600 solution, and put in the above-mentioned titanium sheet. Escherichia coli was used for antibacterial experiments, and the bacterial solution was 10 6 CFU, co-cultivate the titanium sheet and the bacterial solution at 37°C for 6h. The experimental group is the titanium sheet modified w...

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PUM

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Abstract

The invention discloses a preparation method and application of an antibacterial coating on the surface of a dental implant, belonging to the field of biomedical polymer materials. The dopamine is coated on the surface of titanium metal, and then inserted into the trigger point to trigger the ATRP polymerization reaction, and the ring-opening reaction is carried out, and then the antibacterial agent is added under mild conditions of aqueous solution and normal temperature. The antibacterial coating is modified on the surface of the titanium metal tooth post, and the antibacterial agent is attached to the surface at room temperature and in the mild condition of aqueous solution. Compared with other methods of grafting onto the surface in an organic solvent, this method has no organic solvent residue problem, high safety, is more suitable for the environment in the human oral cavity, and has a contact non-release long-term bactericidal effect.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and in particular relates to a preparation method and application of an antibacterial coating on the surface of a titanium metal implant. Background technique [0002] With the development of China's economy and the improvement of medical care, people pay more and more attention to oral problems. Dental implants are favored by people for their advantages of low surgical risk, safety, reliability, and beauty. The best way to fix it. However, a common problem after implant placement is that bacterial infection occurs before or after osseointegration of the implant, which leads to the failure of the implant repair and brings physical pain and economic loss to the patient. Therefore, it is of great clinical significance to construct a coating with antibacterial function on the surface of the implant to prevent the occurrence of bacterial infection. The patent CN 105420680 discloses a pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/54A61L27/34
CPCA61L27/06A61L27/34A61L27/54A61L2300/208A61L2300/404A61L2300/606C08L79/02
Inventor 徐福建赵玉清段顺毋育伟唐志辉
Owner BEIJING UNIV OF CHEM TECH
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