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Method of preparing an osteogenic bone graft

A bone graft, osteogenic technology, applied in the field of preparation of osteogenic bone graft, can solve the problem of not promoting the mixing of anticoagulants

Active Publication Date: 2018-05-11
DEPUY SYNTHES PROD INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The main disadvantage of these methods is that they do not facilitate rapid proportional mixing of anticoagulant into the effluent and are therefore suboptimal in preventing the coagulation cascade from occurring and cellular recovery and viability

Method used

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  • Method of preparing an osteogenic bone graft
  • Method of preparing an osteogenic bone graft
  • Method of preparing an osteogenic bone graft

Examples

Experimental program
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Embodiment

[0095] Cellular material samples were collected from human long bones in protocols (labeled Trials 1 to 10 or Patients 1 to 10) using a commercially available surgical reamer from Depuy Synthes (Reamer / Irrigator / Aspirator (RIA)). The amount of each collected effluent subjected to treatment is shown in Table 3 below.

[0096] Intraoperatively, effluent is collected from a line disposed between the filter assembly and the vacuum source. Additional filters may optionally be used to filter out debris that would cause fouling of the treatment system. Additional filters can also be added to collect additional cell populations that may be clinically valuable. Anticoagulant (heparin in this case) is introduced into the effluent in a controlled manner at a ratio of approximately 6-8 parts effluent to anticoagulant (by weight). An anticoagulant is introduced downstream of the filter assembly. The anticoagulant is introduced into the effluent by the static mixer in a proportionate man...

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Abstract

The present disclosure is directed to a method of preparing an osteogenic bone graft. The method includes introducing an anticoagulant compound into a volume of cellular material including a mononuclear cell population from the intramedullary canal of a long bone; collecting an effluent including the volume of cellular material containing the anticoagulant compound at a collection point; separating a concentrated cell fraction from the effluent, the concentrated cell fraction including the mononuclear cell population and the anticoagulant compound; and preparing an osteogenic bone graft from the concentrated cell fraction.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 199,480, entitled "Methods of Preparing an Osteogenic Bone Graft," filed July 31, 2015, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to osteogenic bone grafts comprising a concentrated cell fraction of a mononuclear cell population and an anticoagulant and methods for preparing the osteogenic bone grafts. Background technique [0004] Nonunions, especially those involving large bony defects in long bones, present significant healing challenges. One method of healing these defects involves the use of an autograft obtained from the medullary canal of a long bone (eg, femur or tibia) using a surgical reamer irrigation aspiration (RIA) system. This system has the advantage of being able to harvest larger volumes of autograft, with lower morbidity and greater speed than, for exam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38A61L27/54
CPCA61L27/54A61L2300/236A61L2300/42A61L2430/02A61L27/3804A61L2300/412
Inventor M.勒米克P.H.科埃略
Owner DEPUY SYNTHES PROD INC
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