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Method for preparing rhodiola kirilowii regel injection by adding activated carbon to medicinal liquid obtained from alcohol precipitation

A technology for preparing activated carbon and adding liquid medicine is applied in the directions of pharmaceutical formulation, drug delivery, and drug combination, which can solve problems such as increasing economic benefits, and achieve the effects of increasing economic benefits, reducing production costs, and improving product safety.

Active Publication Date: 2018-05-04
TONGHUA YUSHENG PHARMA
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  • Application Information

AI Technical Summary

Problems solved by technology

It can more effectively and thoroughly absorb impurities and pigments in the liquid medicine, thereby solving the problem that impurities in the process cannot be completely removed and the color of the liquid medicine is too dark, thereby improving product safety, stability, production efficiency, and product light inspection rate. , while reducing production costs and increasing economic benefits

Method used

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  • Method for preparing rhodiola kirilowii regel injection by adding activated carbon to medicinal liquid obtained from alcohol precipitation

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Embodiment Construction

[0009] After alcohol precipitation, add activated carbon to the medicinal liquid to prepare Dazhu Rhodiola injection. Method: Take 1670g of Dazhu Rhodiola, add water to extract three times, add water 6 times each time, extract for 2 hours, combine the extracts, filter, and concentrate the filtrate to the relative For clear paste with a density of 1.15-1.20 (50°C), add ethanol to make the alcohol content reach 70%, stir well, refrigerate for 24 hours (5-10°C), filter, recover ethanol and concentrate to a relative density of 1.15-1.20 (50°C), add ethanol to make the alcohol content reach 85%, add 3‰ activated carbon and stir for 30 minutes, refrigerate for 24 hours (5-10°C), remove carbon, filter, and recover ethanol from the filtrate and concentrate To a clear paste with a relative density of 1.20-1.30 (50°C), add water for injection to 1000ml, refrigerate for 72 hours, and filter. The filtrate is ultrafiltered with an ultrafiltration column with a molecular weight cut-off of 10...

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Abstract

The invention relates to a preparation method of a traditional Chinese medicinal preparation, namely a method for preparing a rhodiola kirilowii regel injection by adding activated carbon to medicinalliquid obtained from alcohol precipitation. The method comprises the following steps: adding 0.3% of the activated carbon to the medicinal liquid obtained from twice alcohol precipitation, conductingstirring for 30min, implementing refrigerating and removing the carbon. With the application of the method, impurities and pigments in the medicinal liquid can be adsorbed more effectively and more thoroughly, so that the circumstance of a process that impurities cannot be thoroughly removed and medicinal liquid is too dark is solved, and subsequently, the safety, stability, production efficiencyand light inspection yield of the finished product (the injection) are improved; and meanwhile, production cost is reduced and economic benefits are improved.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, that is, a method for preparing Dazhu Rhodiola injection by adding activated carbon to the medicinal liquid after alcohol precipitation. Specifically, activated carbon is added to Dazhu Rhodiola injection after alcohol precipitation, so that the activated carbon can further absorb impurities and pigments in the alcohol phase liquid, thereby more effectively removing impurities and pigments in the liquid, and improving the light inspection pass rate of the finished product at the same time More effective guarantee of drug safety. Background technique [0002] In the existing technology, Dazhu Rhodiola Injection is a patented product exclusively produced by Tonghua Yusheng Pharmaceutical Co., Ltd., and the national drug approval number Z20060361. Properties: This product is light yellow to brownish-yellow clear liquid. Ingredients: Rhodiola rosea. Adaptive sym...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61K9/08A61P9/10
CPCA61K9/0019A61K9/08A61K36/41A61K2236/331A61K2236/51A61K2236/53
Inventor 赵国华王红颖邱久文房宗宝吴海波刘进军崔立萍贺雷周建宇王永亮张仁波
Owner TONGHUA YUSHENG PHARMA
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