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Method for removing safrole from borneol oil

A technology for borneol oil and safrole, which is applied in the field of natural product separation, can solve problems such as time-consuming processing procedures, cumbersome processes, etc., and achieves the effects of strong operability, pure aroma, and increased content

Active Publication Date: 2018-03-20
GUANGDONG AISHENG DAILY CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some restricted use of organic solvents involve solvent residues, so there are very tedious and time-consuming follow-up processing procedures

Method used

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  • Method for removing safrole from borneol oil
  • Method for removing safrole from borneol oil
  • Method for removing safrole from borneol oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 140mL HP21 resin, soak in ethanol, and elute with 95% ethanol until the effluent has no peculiar smell. Then take 2 times column volume of 80% ethanol to replace the solvent in the filler for washing. 10g borneol was adsorbed on the column, the ethanol flow rate was 1 times the column volume per hour, and the sample effluent was collected. After loading the sample, add 80% 1 column volume and 95% 1 column volume ethanol for elution, the flow rate is 2 column volumes per hour, combine the elution effluent and loading effluent, concentrate to remove ethanol, and obtain Brain essential oil.

[0040] Column cleaning: Add 2 times column volume of 95% ethanol at a flow rate of 2 times column volume per hour to clean the adsorbed safrole and impurities. After the elution is completed, prepare for the next column separation.

[0041] The borneol essential oil obtained in the above example 1 and the untreated borneol oil were subjected to GC-MS component detection, where...

Embodiment 2

[0045] Take 140mL HP20 resin, soak in ethanol, and elute with 95% ethanol until the effluent has no peculiar smell. Then take 50% ethanol of 3 times of the column volume, replace the solvent in the filler, and wash. 30g borneol was adsorbed on the column, the ethanol flow rate was 1.5 times the column volume per hour, and the sample effluent was collected. After loading the sample, add 50% 1 column volume methanol, 1.5 column volume 85% methanol for gradient elution, the flow rate is 1 column volume per hour, combine the elution effluent and loading effluent, concentrate to remove the solvent, Get borneol essential oil.

[0046] Column cleaning: Add 2 times column volume of 95% ethanol at a flow rate of 2 times column volume per hour to clean the adsorbed safrole and impurities. After the elution is completed, prepare for the next column separation.

Embodiment 3

[0048] Take 140mL Amberlite XAD-4 resin, soak in ethanol, and elute with 95% ethanol until the effluent has no peculiar smell. Then take 2.5 times of column volume of 70% ethanol to replace the solvent in the filler for washing. 20g borneol was adsorbed on the column, the ethanol flow rate was 2 times the column volume per hour, and the sample effluent was collected. After loading the sample, add 80% 2-times column volume propanol for elution, the flow rate is 1.5 times the column volume per hour, combine the elution effluent and loading effluent, concentrate to remove the solvent, and obtain borneol essential oil.

[0049] Column cleaning: add 3 times column volume of 95% ethanol at a flow rate of 2 times column volume per hour to clean the adsorbed safrole and impurities. After the elution is complete, prepare for the next column separation.

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PUM

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Abstract

The invention provides a method for removing safrole from borneol oil. The method comprises the following steps: (1) pre-treating a column separation filling, putting the filling into a column, and putting the borneol oil into the column; and (2) carrying out elution by virtue of an elution agent, and concentrating, so as to obtain borneol essential oil in which safrole is removed. The method is strong in operability and can be applied to direct expanded production, ''three wastes'' are not generated, the content of dextro-borneol is remarkably increased in the purified borneol essential oil,the purified borneol essential oil has relatively pure fragrance, and the method has wide application prospects and relatively high application values.

Description

technical field [0001] The invention belongs to the field of separation of natural products, and relates to a method for removing safrole from borneol oil. Background technique [0002] Safrole belongs to the first-class precursor substances, and can form strong carcinogens in the process of liver tissue metabolism. It is strictly restricted or even banned in the daily chemical, food, and pharmaceutical industries. Safrole, also known as safrole, has very clear regulations in the "Technical Specifications for Cosmetics": 100mg / kg in finished cosmetics; 50mg / kg in dental and oral hygiene products (prohibited in toothpaste for children). Therefore, the quality control of borneol essential oil is necessary. [0003] Safrole is a colorless to pale yellow liquid with a benzene ring structure and a branched chain at one end with an unsaturated bond. Among the components of borneol essential oil, it belongs to a class of components with relatively low polarity. Compared with born...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B3/10B01D15/08B01D15/20
CPCB01D15/08B01D15/206C11B3/10
Inventor 金志强曾飒高合意吴新星
Owner GUANGDONG AISHENG DAILY CHEM CO LTD
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