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Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers

A technology of variants and amino acids, applied in the direction of drug combination, immunoglobulin, immunoglobulin superfamily, etc., can solve the problem of not providing accurate information of antigen

Active Publication Date: 2018-03-16
IMMATICS BIOTECHNOLOGIES GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, identification of genes overexpressed or selectively expressed in tumor tissues or human tumor cell lines does not provide accurate information on the use of antigens transcribed by these genes in immunotherapy

Method used

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  • Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
  • Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers
  • Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers

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Embodiment Construction

[0162] The ability to stimulate an immune response depends on the presence of antigens that are considered foreign by the host's immune system. The discovery of the presence of tumor-associated antigens raises the possibility of harnessing the host immune system to intervene in tumor growth. Currently, for cancer immunotherapy, various mechanisms of immunity using the humoral and cellular components of the immune system are being explored.

[0163] Specific elements of the cellular immune response specifically recognize and destroy tumor cells. T-cells isolated from tumor-infiltrating cell populations or peripheral blood suggest that these cells play an important role in the innate immune defense against cancer. In particular, CD8-positive T cells play an important role in this response, and TCD8 + Recognizes class I molecules contained in major histocompatibility complex (MHC)-loaded peptides of typically 8 to 10 amino acid residues derived from proteins or defective riboso...

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Abstract

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex(MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Description

[0001] The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the invention relates to immunotherapy of cancer. The present invention also relates to tumor-associated T cell (CTL) peptides used alone or in combination with other tumor-associated peptides, capable, for example, as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses or stimulate T cells in vitro and transfer into patients gauge. Peptides or peptides of the same class that bind to major histocompatibility complex (MHC) molecules can also be targets for antibodies, soluble T cell receptors, and other binding molecules. [0002] The present invention relates to several novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells, which can be used in vaccine compositions to elicit an anti-tumor immune response or as targets for the development of pharmaceut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/74C07K14/725C07K16/28C12N15/12C12N5/0783A61K35/17A61K39/00A61P35/00A61P35/02
CPCA61K35/17A61K39/0011C07K14/7051C07K14/70539C07K16/2833C07K2317/34C12N5/0636A61K39/001148A61K2039/5154A61K2039/5158A61P35/00A61P35/02C07K7/06C07K7/08C07K14/4748A61K39/001154C07K16/3076C12N2501/50C07K16/3046C12N15/1138C12N2310/16
Inventor 安德烈·马尔托尼·温斯切尼克安妮塔·维贝延斯·弗里切哈普瑞特·辛格奥利弗·施尔
Owner IMMATICS BIOTECHNOLOGIES GMBH
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