Multiparameter animal cortex blood flow monitoring device and method

Abstract

The invention discloses a multiparameter animal cortex blood flow monitoring device and method. The device comprises a focusing ultrasound energy converter, an imaging system and a pathology inductionsystem, wherein the focusing ultrasound energy converter is provided with imaging holes in the middle, and is connected with the imaging system and the pathology induction system; the imaging systemis used for using a light source to illuminate the imaging range of the cerebral cortex surface of animals through the imaging holes of the focusing ultrasound energy converter, and capturing and generating images when the light source illuminates the specific position of the cerebral cortex surface of the animals; the pathology induction system is used for utilizing an excitation light source toilluminate the specific position of the cerebral cortex surface of the animals, and inducting the pathology change of the position. By means of the multiparameter animal cortex blood flow monitoring device and method, the purposes that the change of cerebral blood flow caused by pulse transcranial ultrasonic stimulus (pTUS) under the condition of physiology and pathology in cerebral apoplexy can be monitored in real time, and the pTUS nerve regulation effect is evaluated through multiparameter haemodynamics change are achieved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a multi-parameter animal cerebral cortex blood flow monitoring device and method under the influence of transcranial ultrasonic stimulation. Background technique [0002] Pulsed Transcranial Ultrasound Stimulation (pTUS) is a brain neuromodulation technology that has developed rapidly in recent years and has attracted widespread attention. It acts on neurons in the cerebral cortex by passing ultrasound through the intact skull, thereby altering the neural activity of the brain. Compared with other neuromodulation techniques, such as deep brain stimulation (DBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS), pTUS has the advantages of safe, non-invasive and precise stimulation. [0003] Through its neuromodulatory effect, pTUS has unique potential in the treatment of neurological diseases and the study of brain function. For exa...

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Problems solved by technology

However, due to the working methods of traditional ultrasonic transducers, optical imaging technology and photochemical methods, the current experimental conditions cannot complete the real-time monitoring of hemodynamic parameters during pTUS stimulation, let alone realize the real-time monitoring of hemodynamic parameters during photochemical induction. Full pTUS stimulation and real-time monitoring

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