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A kind of hydroxyapatite-polylactic acid biological double-sided mask and its preparation method and application

A technology of hydroxyapatite and paper-like hydroxyapatite is applied in the field of biological materials, which can solve the problems of unreported patents, and achieve the effects of wide application prospect, simple preparation method and short cycle.

Active Publication Date: 2020-01-17
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after searching, there is no report on the patent about the preparation of hydroxyapatite-polylactic acid biological double-sided membrane and its application by layering and compounding hydroxyapatite and polylactic acid

Method used

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  • A kind of hydroxyapatite-polylactic acid biological double-sided mask and its preparation method and application
  • A kind of hydroxyapatite-polylactic acid biological double-sided mask and its preparation method and application
  • A kind of hydroxyapatite-polylactic acid biological double-sided mask and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] ①Preparing the prepared 100 μm hydroxyapatite nanorods into a round cake by suction filtration; wherein, the width of the hydroxyapatite nanorods is 5 nm to 40 nm;

[0034] ② Dissolve 0.01g of L-polylactic acid in 1ml of dichloromethane and stir for 2h;

[0035] ③ Dilute the prepared polylactic acid dichloromethane solution at 0.01ml / cm 2 Spread evenly on the surface of cake-shaped hydroxyapatite, and form a self-film by infiltration and evaporation at a temperature of 60°C to prepare a hydroxyapatite-polylactic acid biological double-sided film with a thickness of 2 μm.

[0036] The above-mentioned hydroxyapatite-polylactic acid biological double-sided mask has hydroxyapatite on one side and polylactic acid on the other side.

Embodiment 2

[0038] ① Prepare the prepared 50 μm hydroxyapatite nanorods by suction filtration to form a round cake; wherein, the width of the hydroxyapatite nanorods is 25nm-40nm;

[0039] ②Dissolve 10g of L-polylactic acid in 2.5ml of dichloromethane and stir for 7h;

[0040] ③ Dilute the prepared polylactic acid dichloromethane solution at 1ml / cm 2 Spread evenly on the surface of cake-shaped hydroxyapatite, and form a self-film by infiltration and evaporation at a temperature of 30°C to prepare a hydroxyapatite-polylactic acid biological double-sided film with a thickness of 1mm.

[0041] The above-mentioned hydroxyapatite-polylactic acid biological double-sided mask has hydroxyapatite on one side and polylactic acid on the other side.

[0042] The resulting hydroxyapatite-polylactic acid biological double-sided film is photographed with a camera, and it can be found that the hydroxyapatite surface and the polylactic acid surface all have different gloss (see figure 1 ).

[0043] Thi...

Embodiment 3

[0046] ① Prepare the prepared 200nm hydroxyapatite nanorods by suction filtration to form a round cake; wherein, the width of the hydroxyapatite nanorods is 5nm-30nm;

[0047] ② Dissolve 20g of L-polylactic acid in 4ml of dichloromethane and stir for 12h;

[0048] ③ Dilute the prepared polylactic acid dichloromethane solution at 0.5ml / cm 2 Spread evenly on the surface of cake-shaped hydroxyapatite, and form a self-film by infiltration and evaporation at a temperature of 0°C to prepare a hydroxyapatite-polylactic acid biological double-sided film with a thickness of 1.5mm.

[0049] The above-mentioned hydroxyapatite-polylactic acid biological double-sided mask has hydroxyapatite on one side and polylactic acid on the other side.

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Abstract

The invention discloses a hydroxyapatite-polylactic acid biological double-sided magical film, which is a double-sided film with one side being hydroxyapatite and the other side being polylactic acidwith a thickness of 0.01[mu]m-2mm; the film is prepared by combining hydroxyapatite with various nano-structures synthesized by a hydrothermal method with polylactic acid at normal temperature and pressure, and using an infiltration and evaporation film self-forming method. The invention also discloses application of the biological double-sided magical film in a tooth bone tissue repair or regeneration process. The biological double-sided magical film provided by the invention is an ideal, safe and excellent biological composite material which has different properties for cells on two surfaces, can promote bone repair while on one surface and prevent postoperative adhesion on the other surface, has simple preparation method and low cost, can be produced on a large scale and has a wide application prospect.

Description

technical field [0001] The invention relates to a hydroxyapatite organic compound material and its preparation method and application, in particular to a hydroxyapatite-polylactic acid biological double-sided mask and its preparation method and application; it belongs to the technical field of biological materials. Background technique [0002] With the development of society, biomedical materials have received deep attention and vigorous development, and the quality and quantity of biomaterials are also getting higher and higher. However, the functions of traditional single materials are limited in many aspects, and it is difficult to meet clinical needs; while composite materials can combine the advantages of various materials to produce an effect of 1+1>2. [0003] Due to its high biocompatibility and natural origin with the human body, hydroxyapatite has always been favored in tooth bone tissue repair engineering. Traditionally, most of the applications of hydroxyapa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/02A61L27/40A61L27/18A61L27/12
CPCA61L27/12A61L27/18A61L31/028A61L31/06A61L2300/112A61L2300/412A61L2430/02C08L67/04
Inventor 刘宏马保金葛少华张珊韩菁王世才段佳志刘锋桑元华
Owner SHANDONG UNIV
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