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Hydroxyapatite-polylactic acid biological double-sided magical film as well as preparation method and application thereof

A technology of hydroxyapatite and polylactic acid, which is applied in tissue regeneration, medical science, surgery, etc., can solve the problems of unreported patents, and achieve the effect of expanding applications, preventing adhesion, avoiding organic reagents and complicated steps

Active Publication Date: 2018-02-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after searching, there is no report on the patent about the preparation of hydroxyapatite-polylactic acid biological double-sided membrane and its application by layering and compounding hydroxyapatite and polylactic acid

Method used

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  • Hydroxyapatite-polylactic acid biological double-sided magical film as well as preparation method and application thereof
  • Hydroxyapatite-polylactic acid biological double-sided magical film as well as preparation method and application thereof
  • Hydroxyapatite-polylactic acid biological double-sided magical film as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] ① The prepared 100 μm hydroxyapatite nanorods are filtered by suction to prepare a round cake; wherein the width of the hydroxyapatite nanorods is 5nm-40nm;

[0034] ② Dissolve 0.01g of L-polylactic acid in 1ml of dichloromethane and stir for 2h;

[0035] ③The prepared polylactic acid dichloromethane solution is adjusted to 0.01ml / cm 2 Spread evenly on the surface of the cake-like hydroxyapatite, and form a film by permeation and evaporation at a temperature of 60°C to prepare a hydroxyapatite-polylactic acid biological double-sided film with a thickness of 2μm.

[0036] The above-mentioned hydroxyapatite-polylactic acid biological double-sided magic film is hydroxyapatite on one side and polylactic acid on the other side.

Embodiment 2

[0038] ① The prepared 50 μm hydroxyapatite nanorods are filtered through suction to prepare a round cake; wherein the width of the hydroxyapatite nanorods is 25nm-40nm;

[0039] ② Dissolve 10g of L-polylactic acid in 2.5ml of dichloromethane and stir for 7h;

[0040] ③Put the prepared polylactic acid dichloromethane solution according to 1ml / cm 2 Spread evenly on the surface of the cake-like hydroxyapatite, and form a film by permeation and evaporation at a temperature of 30°C to prepare a hydroxyapatite-polylactic acid biological double-sided magic film with a thickness of 1mm.

[0041] The above-mentioned hydroxyapatite-polylactic acid biological double-sided magic film is hydroxyapatite on one side and polylactic acid on the other side.

[0042] Take the obtained hydroxyapatite-polylactic acid biological double-sided film with a camera, and it can be found that the hydroxyapatite surface and the polylactic acid surface have different gloss (see figure 1 ).

[0043] Use the scanning e...

Embodiment 3

[0046] ① The prepared 200nm hydroxyapatite nanorods are filtered by suction to prepare a round cake; wherein the width of the hydroxyapatite nanorods is 5nm-30nm;

[0047] ② Dissolve 20g of L-polylactic acid in 4ml of dichloromethane and stir for 12h;

[0048] ③According to 0.5ml / cm of the prepared polylactic acid dichloromethane solution 2 Spread evenly on the surface of the cake-like hydroxyapatite, and form a film by permeation and evaporation at a temperature of 0°C to prepare a hydroxyapatite-polylactic acid biological double-sided magic film with a thickness of 1.5mm.

[0049] The above-mentioned hydroxyapatite-polylactic acid biological double-sided magic film is hydroxyapatite on one side and polylactic acid on the other side.

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Abstract

The invention discloses a hydroxyapatite-polylactic acid biological double-sided magical film, which is a double-sided film with one side being hydroxyapatite and the other side being polylactic acidwith a thickness of 0.01[mu]m-2mm; the film is prepared by combining hydroxyapatite with various nano-structures synthesized by a hydrothermal method with polylactic acid at normal temperature and pressure, and using an infiltration and evaporation film self-forming method. The invention also discloses application of the biological double-sided magical film in a tooth bone tissue repair or regeneration process. The biological double-sided magical film provided by the invention is an ideal, safe and excellent biological composite material which has different properties for cells on two surfaces, can promote bone repair while on one surface and prevent postoperative adhesion on the other surface, has simple preparation method and low cost, can be produced on a large scale and has a wide application prospect.

Description

Technical field [0001] The invention relates to a hydroxyapatite organic compound material and a preparation method and application thereof, in particular to a hydroxyapatite-polylactic acid biological double-sided film, a preparation method and application thereof, and belongs to the technical field of biological materials. Background technique [0002] With the development of society, biomedical materials have received deep attention and vigorous development, and the quality and quantity of biomaterials have become higher and higher. However, the traditional single material is too difficult to meet the clinical needs in many aspects. The composite material can combine the advantages of its various materials to produce 1+1> 2 effects. [0003] Due to its high biocompatibility and autogenousness with the human body, hydroxyapatite has always been favored in tooth and bone tissue repair engineering. Traditionally, most of the application of hydroxyapatite is to transplant the hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/02A61L27/40A61L27/18A61L27/12
CPCA61L27/12A61L27/18A61L31/028A61L31/06A61L2300/112A61L2300/412A61L2430/02C08L67/04
Inventor 刘宏马保金葛少华张珊韩菁王世才段佳志刘锋桑元华
Owner SHANDONG UNIV
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