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Application of Cyanotis arachnoidea extract to preparation of PAH (pulmonary arterial hypertension) preventing and treating drug

A technology of pulmonary arterial hypertension and extracts, applied in the field of medicine, can solve problems such as no related reports

Inactive Publication Date: 2018-02-06
JIANGSU CAREFREE PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant report on the application of dew grass extract in the field of pulmonary arterial hypertension treatment drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 The effect of dew grass extract (hereinafter referred to as LSC) in the monocrotaline-induced pulmonary hypertension model in rats

[0014] Male SD rats, weighing 220g±20g, were prepared by subcutaneous injection of monocrotaline (60mg / kg) to prepare a rat model of pulmonary hypertension. Right heart catheterization was used to detect pulmonary artery blood pressure and hemodynamic indicators. Pulmonary artery blood pressure was detected two weeks after injection to determine whether the modeling was successful, and the animals that were successfully modeled were divided into the following groups (n=10):

[0015] Sham operation group: inject 2 ml / kg of normal saline;

[0016] Model group: injected with normal saline 2 ml / kg;

[0017] LSC high-dose group: 6 mg / kg by injection;

[0018] LSC middle dose group: 3 mg / kg by injection;

[0019] LSC low-dose group: 1 mg / kg by injection;

[0020] After confirming that the modeling was successful, the administration...

Embodiment 2

[0031] Example 2 The effect of dew grass extract (hereinafter referred to as LSC) in chronic hypoxic rat pulmonary hypertension model

[0032] Male SD rats, weighing 220g±20g, placed the rats in a self-made atmospheric hypoxia chamber, flushed nitrogen into the chamber, and maintained the oxygen concentration in the chamber at (10±0.5)%. Intermittent hypoxia was performed every day 8 hours, 6 days a week, 21 days in total; treatment group: inject LSC every day before hypoxia for 21 consecutive days, and give hypoxia treatment at the same time (same as the model group); control group: no treatment.

[0033] The administration of each group was as follows (n=10):

[0034] Control group: intragastric administration of normal saline 2 ml / kg;

[0035] Model group: intragastric administration of normal saline 2 ml / kg;

[0036] LSC high-dose group: 6 mg / kg by intragastric administration;

[0037] LSC middle dose group: 3 mg / kg by intragastric administration;

[0038] LSC low-dose...

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PUM

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Abstract

The invention relates to a new application of dew grass extract in medicine, which belongs to the technical field of medicine. The invention provides a new pharmaceutical application of the dew grass extract, that is, the application in the preparation of drugs for preventing and / or treating pulmonary hypertension. In the monocrotaline-induced pulmonary hypertension model of rats, the dew grass extract was administered, and the pulmonary artery flow velocity and the inner diameter of the pulmonary artery root of the animals in each group were significantly reduced; the average pulmonary artery pressure of the dew grass extract group was lower than that of the model group (P<0.05) , showing that the dew grass extract can significantly reduce the symptoms of pulmonary hypertension caused by monocrotaline, and has the effect of treating pulmonary hypertension. In the model of chronic hypoxic pulmonary hypertension in rats, the dew grass extract was administered, and the research results showed that the increase of pulmonary arterial pressure in rats was significantly reduced, suggesting that the dew grass extract could inhibit the increase of pulmonary arterial pressure in chronic hypoxic rats.

Description

technical field [0001] The invention relates to a new application of dew grass extract in medicine, in particular to a new application in the preparation of drugs for preventing and / or treating pulmonary hypertension. It belongs to the field of medical technology. Background technique [0002] Pulmonary hypertension, as a multiple chronic disease among cardiovascular diseases, is secondary to heart, lung, systemic diseases or unknown causes, and is mainly manifested as persistent increase in pulmonary artery pressure and pulmonary vascular resistance, leading to progressive dyspnea. One of the major diseases that threaten human health in society. According to the latest clinical classification proposed by the 2009 European Society of Cardiology Guidelines for the Diagnosis, Diagnosis and Treatment of Pulmonary Hypertension (hereinafter referred to as the Guidelines), Pulmonary Arterial Hypertension (PAH) is a rare chronic fatal disease in PH that seriously affects the life ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/12
CPCA61K36/88
Inventor 苏梅马瑞
Owner JIANGSU CAREFREE PHARM CO LTD
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